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Quiz 14b Immune system

Terms in this set (33)

Which laboratory test is used to determine the progress of an HIV infection?

Western blot
CD4 and CD8 counts
ELISA
Viral load
Viral load
Some patients with HIV who are treated with Abacavir develop a significant life-threatening rash and disease known as Stevens-Johnson syndrome that is mediated by T-lymphocytes. Which type of hypersensitivity reaction is this an example of?
Type IV
What is the mechanism for injury when an incompatible unit of blood is transfused into a recipient?
***Type III hypersensitivity reaction

prob; Red cell lysis following complement activation
The basement membrane of the nephron is rich in collagen. The production of autoantibodies leads to

Sjögren syndrome.
Goodpasture syndrome.
Wiskott-Aldrich syndrome.
delayed hypersensitivity type III.
Goodpasture syndrome.
Which test is the most specific for rheumatoid arthritis?

C-reactive protein
Erythrocyte sedimentation rate
Rheumatoid factor
Anti-cyclic citrullinated peptide antibody
Anti-cyclic citrullinated peptide antibody
Which drug can be used to combat the effect of a type I hypersensitivity reaction?

Antihistamine
Antianalgesic
Antibiotic
Antiarrhythmic
Antihistamine
Board Review Question: The immunoglobulin class typically found to be present in saliva, tears and other secretions is:

IgA
IgG
IgM
IgD
IgA
Board Review Question: The prevalence of immune complexes indicates

polyclonal hypergammaglobulinemia
inflammatory tissue injury
protection from complement-dependent neutrophil chemotaxis
normal host response to antigenic exposure
normal host response to antigenic exposure
Board Review Question: Immediate hypersensitivity is most commonly associated with

contact dermatitis
transfusion reaction
anaphylactic reaction
bacterial septicemia
anaphylactic reaction
Board Review Question: The IgM molecule is a

dimer
trimer
tetramer
pentamer
pentamer
Board Review Question: Measurement of serum levels of which of the following immunoglobulins can serve as a screening test for multiple allergies?

IgE
IgA
IgG
IgM
IgE
Board Review Question: High titers of antimicrosomal antibodies are most often found in

rheumatoid arthritis
systemic lupus erythematosus
chronic hepatitis
thyroid disease
thyroid disease
Board Review Question: Antinuclear antibody tests are performed to help diagnose

acute leukemia
hemolytic anemia
rheumatoid arthritis
lupus eythematosus
lupus eythematosus
Board Review Question Macrophages are characterized by

in vitro synthesis of immunoglobulins
larger amounts of rough endoplasmic reticulum
cytoplasmic receptor for the C3 complement
surface CD3 expression
cytoplasmic receptor for the C3 complement
Board Review Question: Which class of immunoglobulin is thought to function as an antigenic receptor site on the surface of immature B lymphocytes?

IgD
IgA
IgM
IgG
IgD
Board Review Question : Macrophage phagocytosis of bacteria in enhanced by which of the following

secretory piece
hapten
antigen
opsonins
opsonins
Board Review Question: Substances that are antigenic only when coupled with a protein carrier are

allergens
haptens
adjuvants
opsonins
haptens
Board Review Question: Antihistamines

stimulate IgE antibody production
block histamine receptors
stimulate IgG blocking antibodies
bind histamine
block histamine receptors
Board Review Question: Humoral antibodies are produced by which cells?

T-lymphocytes
macrophages
neutrophils
B-lymphocytes
B-lymphocytes
Board Review Question: Which of the following mediators is released during T-cell activation?

lymphokines
thymosin
immunoglobulins
serotonin
lymphokines
Board Review Question: Antibodies are produced by

B cells
killer cells
mast cells
marrow stem cells
B cells
Board Review Question: Rheumatoid factor is

IgG or IgM autoantibody
an antigen found in the serum of patients with rheumatoid arthritis
capable of forming circulating immune complexes only when IgM-type autoantibody is present
identical to the rheumatoid arthritis precipitin
IgG or IgM autoantibody
Board Review Question: Antibody class and antibody subclass are determined by major physiochemical differences and antigenic variation found primarily in the

constant region of light chain
constant region of heavy and light chains
constant region of heavy chain
variable region of heavy and light chains
***constant region of heavy chain
Board Review Question: Which of the following is decreased in serum during the active stages of systemic lupus erythematosus?

immune complexes
complement C3
anti-DNA
antinuclear antibody
complement C3
Board Review Question: To which of the following classes do red cell antibodies usually belong?

IgG
IgE
IgA
IgD
***IgA
Board Review Question: Which of the following immunoglobulins is the most efficient agglutinin?

IgM
IgA
IgE
IgG
IgM
Board Review Question: Which of the following is an organ specific autoimmune disease?

rheumatoid arthritis
progressive systemic sclerosis
Addison's disease
myasthenia gravis
Addison's disease
Board Review Question: Cells known to be actively phagocytic include:

neutrophils, monocytes, basophils
lymphocytes, eosinophils, monocytes
neutrophils, eosinophils, monocytes
monocytes, lymphocytes, neutrophils
***lymphocytes, eosinophils, monocytes
Board Review Question: Which of the following is an important cellular mediator of immune complex tissue injury?

eosinophil
neutrophil
basophil
monocyte
neutrophil
Board Review Question: Antibodies composed of IgG immunoglobulins

are larger molecules than IgM antibodies
Occur during the primary response to antigens
can be detected in saline crossmatches
can cross the placenta from mother to fetus
can cross the placenta from mother to fetus
Board Review Question: Patients suffering from Waldenstrom's macroglobulinemia demonstrates excessively increased concentrations of which of the following?

IgD
IgG
IgM
IgA
IgM
Which immunoglobulin responds within a few minutes after exposure to an antigen and constitutes a type 1 hypersensitivity reaction?

IgG
IgA
IgM
IgE
IgE
Which type of hypersensitivity reaction is cell-mediated and is delayed in the rate of development?

Type I
Type II
Type III
Type IV
Type IV
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