Created by
Terms in this set (11)
Epidemiologic data - positive association between agent and disease are accepted as the most convincing evidence about human risk. Limitations: low exposure/low risk, number of person is small, latend period exposure/risk is long, exposure are multiple
Animal bioassay- mainstay in hazard Identification. Studies of chronic exposure in rats and mice. Applicable to humans, confident finding in both sex and species.
Cellular (in vitro) data- mechanism of action is known, does not consider the whole organism
Structure-activity relationships- rapid and inexpensive, Use information on molecular structure and known toxic effects of a "training" set of chemicals to set up a predictive model.•Works best for chemicals within a structural class (i.e., with similar structures)
Animal bioassay- mainstay in hazard Identification. Studies of chronic exposure in rats and mice. Applicable to humans, confident finding in both sex and species.
Cellular (in vitro) data- mechanism of action is known, does not consider the whole organism
Structure-activity relationships- rapid and inexpensive, Use information on molecular structure and known toxic effects of a "training" set of chemicals to set up a predictive model.•Works best for chemicals within a structural class (i.e., with similar structures)
relative weights-studies with the differing results?
positive outweigh negative result?
significance of positive finding if route of exposure is different?
should evidence be weighed combined?
What are the interpretation when treatment results in significant increases in some tumors but significant decreases in others?•Should benign and malignant tumors be counted equally?
What additional weight does structural similarity (through computer modeling) add to the results of animal bioassays? Are the results from computer modeling alone ever adequate for hazard identification?
positive outweigh negative result?
significance of positive finding if route of exposure is different?
should evidence be weighed combined?
What are the interpretation when treatment results in significant increases in some tumors but significant decreases in others?•Should benign and malignant tumors be counted equally?
What additional weight does structural similarity (through computer modeling) add to the results of animal bioassays? Are the results from computer modeling alone ever adequate for hazard identification?