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Case Studies

Terms in this set (27)

The FDA requires which of the following to appear in polyspecific AHG?
Anti-C3d and anti-IgG
Hybridoma cells can be made by fusing:
murine B cells with myeloma cells
Which of the following initiates the classical complement cascade?
C1q is fixed to antibody
A male patient who weighs 240 lbs. has approximately how many liters of blood?
7.6 L
The KB test shows 30 fetal cells per 2,000 cells. If the mother weighs 75 kg, how many vials of RhIg (standard dose) should be administered?
4 vials
In which of the following transfusion reactions do symptoms usually appear after > 24 hours?
PTP
Of the following, which antibody specificity has the greatest potential for causing the most severe HDFN?
Anti-Jsa
Which of the following procedures assesses the risk of fetal anemia by monitoring the middle cerebral artery peak systolic velocity?
Color Doppler Ultrasonography
AABB Standards requires blood for neonatal transfusion to be:
compatible with maternal antibodies
Storage lesion in CPDA-1 includes:
Decreased 2,3-DPG levels
The correct shelf life for pooled cryoprecipitate is:
4 hours
Which of the following would result in temporary donor deferral?
Hematocrit 35%
A unit of red cells expiring in 35 days is split into 5 small aliquots using a sterile pediatric quad set and a sterile connecting device. Each aliquot must be labeled as expiring in:
35 days
Transfusion of 1 unit of packed red blood cells is expected to increase the patient's:
HCT by 3-5%
Adsorption with autologous cells is indicated when:
the patient has not received a transfusion within the past 3 months
Adsorption with allogeneic red cells:
is meant to detect the most common underlying alloantibodies only, if present
Mannitol can be found in which of the following?
AS-1
Which of the following would be the most importantdiagnostic tool for hemolytic anemia?
Reticulocyte countD.
In rare cases of WAIHA, a DAT may be negative. In such cases, patient's cells could be coated with which of the following?
IgA
The most appropriate way to ascertain STAT information regarding a patient's phenotype when the DAT is positive is to use:
monoclonal reagents
A 32-year-old, female trauma patient has received 4, type O negative units of pRBCs and 4 units of AB FFP. After a type and screen is performed, the MLS observes the following results. What do you do next?www.PresentationPro.comAnti-AAnti-BAnti-DA1 CellB Cell3+ MF002+4+
Investigate A subgroup with anti-A1.
Investigate A subgroup with anti-A1. How do you do this?
Test patient's cells with Dolichos biflorus lectin•Test patient's plasma with 2 more A1 Cells and 3 A2 Cells (Rule of 3)
In X-Linked recessive inheritance patterns, the father always expresses the trait but never passes it to his sons. Examples include: McLeod Phenotype, CGD, and Hemophilia A. (XGA antigen expression is an example of an X-Linked dominant trait).
1,000 people are phenotyped for the "X" antigen. If 80% are X-positive and 20% are X-negative, what percentage of the population is X/X?
80% are X-positive and 20% are X-negative (homozygous recessive x/x)Recall the Hardy-Weinberg equation: p2 + 2pq + q2 = 1q2 represents the percentage of homozygous recessives, so q2 = 0.20.Solve for q by taking the square root of 0.20, which equals 0.45 If q = 0.45, plug into the equation p + q = 1p + 0.45 = 1
p = 0.55Now, plug the values for p and q back into the equation:p2 + 2pq + q2 = 1(0.55)2 + 2(0.55)(0.45) + (0.45)2 = 10.30 + 0.50 + 0.20 = 1X/X = 30%, X/x = 50%, x/x = 20%
Which of the following is/are X-linked recessive?-McLeod phenotype-CGD-XGA antigen expression-Hemophilia A
In X-Linked recessive inheritance patterns, the father always expresses the trait but never passes it to his sons. Examples include: McLeod Phenotype, CGD, and Hemophilia A. (XGA antigen expression is an example of an X-Linked dominant trait).
Which of the following is an example of a phenotype arising from a homozygous inheritance pattern?-Jk(a-b-)-R1r"-Jk(a+b+)-Fy(a+b+)
Jk(a-b-) is a rare phenotype that can arise when the inherited genes are homozygous JK/JK
The FD&C Act requires blood product manufacturers to register with the FDA, obtain biologics licenses, and follow:_____________-
cGMP
Under __________, standards for laboratory personnel, QC and QA are based on test complexity and potential harm to a patient. Sanctions are enforced when laboratories fail to meet the standards.
CLIA
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