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PHARM TEST #4 = BEHAVIORAL HEALTH
Terms in this set (20)
What is the MOA of Selective Serotonin Reuptake Inhibitors (SSRI)?
Highly selective blockade of serotonin transporter (SERT)
- Allosterically inhibit transporter, binding at a site other than that of serotonin
What is the MOA of Serotonin-Norepinephrine Reuptake Inhibitors (SNRI)?
o Moderate selective blockade of SERT & NET (SERT >> NET)
o Heterocyclic drugs that block NE & 5-HT transporters, but lack the alpha blocking, anticholinergic + antihistaminic action of TCAs
Which TCA has the shortest half-life + largest volume of distribution (Vd)?
What is the result of MAO inhibitors preventing the breakdown of tyramine?
- high serum levels enhance peripheral noradrenergic effects (raise BP)
- malignant HTN + stroke + MI
- Low Tyramine Diet (avoid aged cheeses, tap beer, soy products, dried sausages)
What is the name of the life-threatening interaction of SSRIs + MAO Inhibitors?
What is the most potent SSRI?
What are the adverse effects of thioridazine?
- retinal deposits, retinitis pigmentosa, brown vision
- minor abnormalities of T-waves, ventricular arrythmias
What is the atypical antipsychotic with the greatest risk of QT interval prolongation?
Which neurotransmitter is consistently associated with extrapyramidal toxicity?
High D2/Dopamine Potency
What is the effect of nefazodone on the CYP3A4 isoenzyme + its effect on triazolam?
- Raise level + exacerbate adverse effects of 3A4 dependent drugs
- Increases ↑ levels of Triazolam
What is the 1st line mood stabilizer for rapid cycling?
What is the toxic effect level of lithium?
Plasma Levels > 1.4mEq/L
Which anticonvulsant is used as a mood stabilizer that can cause rare, but serious & sometimes fatal blood dyscrasias (bone marrow suppression)?
Which anticonvulsant is used as a 1st line therapy for maintenance tx of bipolar depression?
What drug is used to tx benzodiazepine overdose?
What are the 3 Benzodiazepine-1 Receptor Agonists (Z-hypnotics)?
What is the non-stimulant used to tx ADHD?
What is the "aversive" therapy used in aiding abstinence from alcohol?
What is the FDA-approved tx option for opioid dependence for pregnant women?
What is the drug used as tx for opioid dependence that is a partial agonist at the μ-opioid receptor?
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