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mom is alloimmunized from baby's RBCs and mom makes antibodies to baby RBCs and starts lysing the baby cells.
-results in erythroblastosis fatalis
If IgM is detected on an antibody ID panel and IgM is detected, is that clinically significant?
no- only if IgG is detected
if a babies Rh positive blood mixes with a mothers Rh negative blood how do you remove the baby's cells?
add anti-D to mom's cells and rosettes will form (qualitative). Because the anti-D will bind with the baby cells.
Kleiheiuer-Betke test facts
-stains hgb F
-uses acid buffer on slide
-can count hgb F cells
moms hgb A shows as ghost cell
if a pregnant woman is injured and intrauterine bleeding occurs, what needs done?
-O neg blood less than 7 days old
-CMV neg blood
-blood neg for hgb's
How do you prevent HDN?
Use rogam 72 hours after delivery if baby is RH pos (1st baby)
for second pregnancy, rogam at 28 weeks and after birth if baby is Rh pos
how do you determine if there is an internal bleed in a pregnant woman?
draw mom's blood and perform a rosette test
KB test: what specimen is NOT suitable for testing fetal-maternal hemorrhage
(used for QC purposes only)
KB test: what stains hot pink
-lymphocytes (nucleated or granulocytic)
after giving birth to an Rh positive infant, a mom who previously tested Rh negative may test weak D pos. Why?
baby's blood crossed over into mom's blood and she developed antibodies
a mother has an anti-D and an infant who has HDFN symptoms. the infant tests are Rh neg. what may cuase a false neg Rh test in the infant?
Mom's blood crossed over into baby's blood so mom's antibodies are being detected in baby
-immediate access to data
-barcodes reduce misidentification
-good reports from data
minimum requirements of lab instruments
-access code for security
-unique accession numbers
-unique file for each assay
-record date, time and collector
-store and print bar codes
-interface with current system
cold AIHA reaction
-PCH- auto anti-P and donath landsteiner Ab
-DAT pos due to C3d
-adsorption may be necessary
drug induced reaction
-increase doses of IV penicillin
-second generation cefalosporin
-stop drug= stop reaction
Why do we elute serum
so Ags in serum won't get in the way of tests. We can get it out of the way and continue searching for what we are looking for.
pos DAT can tell us:
-if pt has been transfused, they may have an alloantibody coating the transfused cells
-if pt hasn't been transfused, they may have an autoantibody coating their own cells
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