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Chapter 5 Integumentary System

STUDY
PLAY
organs that make up the integumentary system
skin, nails, hair follicles, sebaceous glands, sweat glands, specialized nerve endings
SKIN
one of the largest organs in the body, is .5mm to 4.0 mm thick
epidermis
superficial region of skin
dermis
middle region of skin
hypodermis
superficial fascia- deepest region
skin layer
Epidermis
epithelial tissue that attaches to dermis- keratinized stratified squamous epithelium. HAS NO BLOOD VESSELS (AVASCULAR)
cells of epidermis
keratinocytes, melanocytes, langerhans cells merkel cells (tactile cells)
keratinocytes
produce fibrous proteins, 90% of cells, connected by desmosomes, produced in stratum basale and pushed to surface, dead when they reach the surface 25-45 days from production to sloughing off FUNCTION: protective barrier
melanocytes
10-25% of cells in lower epidermis,produce brown-black pigment called melanin, melanin is accumlated in membrane bound granules called melanosomes and transferred to nearby keratinocytes
merkel cells
touch receptors, only present in stratum basale, form a merkel disc for sensation of light touch
everyone has the same number of melanocytes
true
langerhans cells
immune system cells which detect and present antigens to other immune system cells, macrophages that ingestantigens and activate immune system
...
5 layers of epidermis
stratum corneum, stratum lucidum, stratum granulosm, stratum spinosum, stratum basale
most superficial layer, 20-30 layers of dead cells represented only by flat membrane sacs filled with keratin. Glycolipids in extracellular space
stratum corneum
three to five layers of flattened cells, organelles deteriorating, cytoplasm full of lamellated granules that release lipids and keratohyline granules
stratum granulosum
several layers of keratinocytes unified by desomoes, cells contain thick bundles of intermediate filaments made of pre-keratin
stratum spinosum
deepest epidermal layer, one row of actively mitotic stem cells, some newly formed cells become part of the more superficial layers
stratum basale
thick skin- bottoms of toes, soles, palms fingertips
5 layers of skin
stratum basale
anchored to basement membrane, consists of single layer of mostly stem cells undergoing mitosis to become keratinocytes, a few melanocytes that create skin pigment and occasionally merkel cells
Stratum Spinosum (prickly layer)
7-10 layers of cells, mostly keratinocytes with a few langerhans cells and some melanin granules
stratum granulosum
thin consists of 3-5 cell layers in which drastic changes in keratinocyte appearance occurs (cells flatten) keratohyaline -granules- precursors to keratin, lamellated granules- waterproofing glycolipids
cells in stratum granulsum die because
they are getting too far away from blood vessels in dermis,, they are programmed to die
stratum lucidum
only found in thick skin of palms, soles, fingerips, and bottoms of toes- 3-5 layers of flat clear dead keratinocytes
stratum corneum
horny layer, 20-30 layers of dead keratinocytes, FUNCTIONS protects from abrasion, penetration, waterproofs,
contains flycolipid between cells to waterproof skin
stratum corneum
serves as a physical barrier again light, heat, microorganisms, water and chemicals
startum corneum
callus
thickening of epidermis due to frequent friction or abrasion
epidermal growth factor
protein hormone which stimulates stratum basale cells to undergo mitosis
found in saliva of many mammals and produced by other cells
epidermal growth factor
Dermis
second major skin region containing strong flexible connective tissue
cell types include fibroblasts, macrophages and occasionally mast cells
dermis
rich supply of blood vessels and nerves, contains glands and hair follicles
dermis
Papillary layer (dermis)
superfical layer that makes up 20% of dermis, areolar connective tissue with collagen and elastic fibers and blood vessels
composed of small fingerlike projections called dermal papillae which push up into epidermis
papillary layer
dermal papillae (papillary layer of dermis)
contains capillary loops, meissnesr's corpuscles(touch receptors) and free nerve endings for pain. FUNCTION: to increase surface area of contract between epidermis and dermis, to increase diffusion and bettwe resistance to abrasion
fingertips
caused by dermal ridges and dermal papillae resulting in erpidermal ridges FUNCTION to increase friction for gripping
reticular layer (deep layer of dermis)
80 % of dermis, dense irregular connection tissue with thich collagen and coarse elastic fibers
collagen fibers in the layer add strendth and resiliency to the skin, elastic fibers provide stretch-recoil properties
reticular layer
contains hair follicles, nerves, sebaceous glands, sweat glands, pacinian corpuscles and blood vessels
reticular layer
cleavage or tension lines
skin markings that seperations between bundles of collagen that run parallel to skin surface
flexure lines
skin markings that are dermal folds that occue at or near joints where the dermis is tightly secured to deeper structures- palms, wrists, fingers, soles and toes
stretch marks (striae)
result from dermal tearing, casused by severe strectching -homeostatic imbalance
blisters
result from tearing of weak areolar CT of papillary layer
Subcutaneous tissue (hypodermis and superficial fascia)
composed of adipose tissue, and areolar connective tissue, contains cold senestive nerve endings
pigments that contribute to skin color
melanin, carotene, hemoglobin
melanin
different forms that range in color, produce melanocytes located in the stratum basale of the epidermis
accumulates in membrane-bound granules called melanosomes that are moved to ends of melanocytes processes
melanin
melanosomes are taken up by basal keratinocytes
true
local accumulations of melanin results in freckles, moles, and age spots
true
carotene
yellow to orange pigment found in carrots, egg yolks and tomatoes, localizes in the stratum corneul and adipse tissue, most obvious in palms and soles
high consumption of carotene-containing foods gives skin a yellow hue
true
yellowish skin of some asian people is sue to variants of carotene
false- melanin is the cause
hemoglobin
a red pigment in red blood cells, skin is translucent when little melanin and carotene are present (fair people)
red-pink color of blood in dermal capillaries shows through skin as pinkish hue
true-hemoglobin
cyanosis
blood and skin of caucasians appear blue when hemoglobin is poorly oxagentaed- during heart failure, sever respiratory disorders , if a baby does not breath shortly after birth
erythema
redness of skin, fever, hyertension, inflammation, allergy, blushing
palor or blanching
pale skin, anemia, low blood pressure, during fear, anger and certain types of emotional stress
jaundice
abnormal yellowing of the skin caused by a liver disorder(yellow bile pigments)
bronzing
bronzing of skin sign of addisons disease
bruises
blood from ruptured capillaries below skin which clotted beneath the skin
hematomas
clotted blood masses
derivatives of the epidermis
sweat glands, sebaceous glands, hair and hair follicles, nails
sweat glands
3-4 million per person, 2 types: eccrine and apocrine
eccrine sweat glands
most common type, simple, coiled tubular gland that carries sweat through dermis to surface pores
found everywhere EXCEPT lips, nail beds, nipples, external genitalia ear drums
eccrine sweat glands
sweat
hypotonic to plasma, 99% water,some salts, vitamin C FUNCTION: cools body and eliminates waste
apocrine sweat glands
secretes by exocytosis, found in axilla and pubic region, ducts connect to hair follicles so hair conducts secretion into air
bacteria decompose of fat and proteins resulting in odor; stimulated by emotional stress and sexual excitement
apocrine sweat glands
mammary gland
sweat glands specialized to secret milk
ceruminous glands
found in skin of external ear canal to secrete ear wax
sebaceous glands
widely distributed except on the palmer and planter surfaces of hands and feet,
develops from hair follicles, secretes oil onto hairs in hair follicles, micute of fats, cholesterol, proteins and salts
sebaceous glands
Functions: softens hair and skin, reduces water evaporation, bacterial
sebaceous glands
hair
functions" protects from sunlight, heat loss, particles and insects
hair is distributed over the enitre skin surface expect palms, soles, lips, nipples and portions of external genitalia
true
hair is filamentous strands composed of
dead, hard keratinized cells produced by hair follicles
hair shaft
above epidermis
hair root
in epidermis and dermishollow tube that holds hair
medulla
central core of large cells and air spaces
cortex
thickest layer,keratinized pigmented flattened cells- surrounds medulla
cuticle of hair
single outer layer of keratinized cells that overlap each other- surrounds cortex
hair follicle
extends from epidermal surface into dermis- lining of hair shaft
connective tissue root sheath
dermis-blue exterior area on outer follicle wall
glassy membrane
thickened basement membrane- dark blue membrane between CT root sneath and external epithelial root sheath
external epithelial root sheath
tissue after the glassy membrane
internal root sheath
tissue after external epithelial root sheath before cuticle
hair bulb
expanded deep end, enlarged base of follicle-bottom of follicle directly under root
hair papilla of hair bulb
connective tissue with many blood vessels
hair matrix of hair bulb
ring of actively didving cells
sebaceous glands are with each hair
true
hair follicle receptor
sensory nerve endings around each hair bulb, stimulated by bending a hair
arrector pili muscle
smooth muscle that runs from connective tissue root sheath to suferficial dermis- contracts hair vertically
cause goose bumps, decreases heat loss by increasing the dead air space above skin, induced by stimuli
arrector pili muscle
hair growth
2 cycles growth phase and resting phase
lasts 6-10 years in scalp, 3-4 months in eyebrows
growth phase
last 1-3 months
resting phase
vellus
pale, fine body hair of children and adult femals
terminal
coarse, long hair of eyebrows, scalp, axillary and pubic regions
hirsutism
excessive hairiness in women due to abnormal secretion of androgens
hair pigments
melanins in medulla and cortex
dark hair
true melanin
blonde and red hair
melanin variants with iron and sulfur
gray/white hair
decreased melanain production, increased air bubble in shaft
alopecia
hair thining in both sexes after age of 40
frank(true) baldness
genetically determind and sex-influenced condition
nail
scalelike modification of epidermis on distal dorsal surface of fingers and toes
nail body
pink due to blood underlying capillaries
lunula
white cresent shape at bottom of nail
free edge
white edge of nail
nail root
anchored in skin
cuticle
thick stratum corneum
Chemical Barrier
low pH secretions(acid mantle) and defensisn retard bacterial activity
melanin provides a chemical pigment to prevent UV damage to the viable skin cells
true
physical/mechanical barriers
keratin and glycolipids block most water and water-soluble substances
The most abundant cells of the epidermis.
Keratinocytes
The protein found in the epidermis that is responsible for toughening the skin
Keratin
Cells plus a disc-like sensory nerve ending that functions as a sensory receptor for touch
Merkel disc
Skin macrophages that help activate the immune system
Epidermal dendritic cells
Cell remnants of the stratum corneum
Cornified keratinocytes
The layer of the epidermis where the cells are considered protective but nonviable
Stratum corneum
The glands that serve an important function in thermoregulation
Sudoriferous glands
The layer that contains the mitotic viable cells of the epidermis
Stratum basale
Hair that lacks pigment and is often called "immature hair."
Vellus
May indicate embarrassment, fever, hypertension, inflammation, or allergy.
Erythemia
May indicate fear, anger, anemia, or low blood pressure
Pallor
Usually indicates a liver disorder
Jaundice
Appearance of a permanent tan; bronzing.
addisons disease
A bluish color in light-skinned individuals
Cyanosis
The apocrine sweat glands are fairly unimportant in thermoregulation
True
Skin surface markings that reflect points of tight dermal attachment to underlying tissues are
called epidermal ridges
false
The dense fibrous connective tissue portion of the skin is located in the reticular region of the
dermis
true
The outermost sheath of a hair follicle is the connective tissue root sheath
true
The protein found in large amounts in the outermost layer of epidermal cells is collagen.
false
Joe just burned himself on a hot pot. A blister forms and the burn is painful. Joe's burn would
best be described as a third-degree burn
false
Destruction of the matrix of the hair bulb would result in its inability to produce oil
false
The hyponychium is commonly called the cuticle
false
The reason that the nail bed appears pink is the presence of a large number of melanocytes in
the underlying dermis
false
During the resting phase of hair growth, the matrix is inactive and the follicle atrophies.
true
The most dangerous skin cancer is cancer of the melanocytes.
true
The skin is not able to receive stimuli because the cells of the epidermis are not living and therefore there are no sensory receptors in the skin
false
The dermis is rich in blood vessels and nerve fibers.
true
The hypodermis is composed of adipose and dense connective tissue
false
A physician is often able to detect homeostatic imbalances in the body by observing changes in the skin color
true
When an individual is exposed to extremely low air temperatures, the dermal blood vessels will dilate so that blood and heat will be dissipated.
false
Regardless of race, all human beings have about the same number of melanocytes
true
Ceruminous glands are modified merocrine glands
false
The stratum corneum (outermost layer of skin) is a zone of approximately four layers of viable cells that are able to synthesize proteins that keep the outer layer of skin smooth and soft
false
The pinkish hue of individuals with fair skin is the result of the crimson color of oxygenated hemoglobin (contained in red blood cells) circulating in the dermal capillaries and reflecting through the epidermis.
true
Hair growth and density are influenced by hormones, nutrition, and, in some cases, lifestyle
true
When a patient is said to have "third-degree burns," this indicates that the patient has burns that cover approximately one-third of the body.
false
Sweat glands continuously produce small amounts of sweat, even in cooler temperatures
true
Melanomas are rare but must be removed quickly to prevent them from metastasizing
true
________ is an inherited condition that affects the heme pathway; it leaves the skin scarred and gums degenerated, and may have led to the folklore about vampires.
Porphyria
A needle would pierce the epidermal layers of the forearm in which order
corneum, granulosum, spinosum, basale
The major regions of a hair shaft include all of the following except ________.
external root sheath
Acne is a disorder associated with ________.
sebaceous glands
The dermis ________.
has 2 layers
Which muscles attached to the hair follicles cause goose bumps
arrector pili
If a splinter penetrated the skin into the second epidermal layer of the sole of the foot, which cells would be damaged?
lucidum
Which of the following cutaneous receptors is specialized for the reception of touch or light pressure?
Meissner's corpuscles
Which of the following is a skin sensory receptor for touch?
Meissner's corpuscle
Which statement correctly explains why hair appears the way it does
Kinky hair has flat, ribbonlike hair shafts
Sudoriferous glands vary in distribution over the surface of the body. Which of the following is correct?
Ceruminous glands secrete cerumen, which is thought to deter insects
Although the integument is a covering, it is by no means simple, and some of its functions include ________.
resident macrophage-like cells whose function is to ingest antigenic invaders and present
them to the immune system
The function of the root hair plexus is to ________.
allow the hair to assist in touch sensation
Vernix caseosa is a ________.
whitish material produced by fetal sebaceous glands
The ________ gland is a modified sudoriferous gland that secretes wax
ceruminous
Nutrients reach the surface of the skin (epidermis) through the process of ________.
diffusing through the tissue fluid from blood vessels in the dermis
The reason the hypodermis acts as a shock absorber is that ________.
the major part of its makeup is adipose, which serves as an effective shock absorber
Which type of skin cancer appears as a scaly reddened papule and tends to grow rapidly and metastasize
Squamous cell carcinoma
Keratinocytes are an important epidermal cell because they ________.
produce a fibrous protein that gives the skin much of its protective properties
Melanocytes and keratinocytes work together in protecting the skin from UV damage when keratinocytes ________
accumulate the melanin granules on their superficial portion, forming a UV-blocking pigment
layer
The epidermis consists of five layers of cells, each layer with a distinct role to play in the health, well-being, and functioning of the skin. Which of the following layers is responsible for
cell division and replacement?
stratum basale
The integumentary system is protected by the action of cells that arise from bone marrow and
migrate to the epidermis. Which of the following cells serve this function?
macrophages called epidermal dendritic cells
Water loss through the epidermis could cause a serious threat to health and well-being. Which of the following protects us against excessive water loss through the skin?
Lamellated granules of the cells of the stratum granulosum, a glycolipid that is secreted into
extracellular spaces
The dermis is a strong, flexible connective tissue layer. Which of the following cell types are likely to be found in the dermis?
fibroblasts, macrophages, and mast cells
The dermis has two major layers; which of the following constitutes 80% of the dermis and is responsible for the tension lines in the skin?
the reticular layer
Despite its apparent durability, the dermis is subject to tearing. How might a person know that the dermis has been stretched and/or torn?
The appearance of visible, silvery-white scars is an indication of stretching of the dermis
The papillary layer of the dermis is connective tissue heavily invested with blood vessels. The superficial surface has structures called:
dermal papillae.
The design of a person's epidermal ridges is determined by the manner in which the papillae rest upon the dermal ridges to produce the specific pattern known as handprints, footprints, and
fingerprints. Which of the following statements is true regarding these prints or ridges?
They are genetically determined, therefore unique to each person
Which of the following statements indicates the way in which the body's natural defenses protect the skin from the effects of UV damage?
Prolonged exposure to the sun induces melanin dispersion, which in turn acts as a natural
sunscreen.
Changes in the color of skin are often an indication of a homeostatic imbalance. Which of the following changes would suggest that a patient is suffering from Addison's disease?
The skin takes on a bronze or metallic appearance
An epidermal dendritic cell is a specialized ________.
phagocytic cell
What are the most important factors influencing hair growth?
nutrition and hormones
Which of the following statements best describes what fingernails actually are
Fingernails are a modification of the epidermis
Sudoriferous (sweat) glands are categorized as two distinct types. Which of the following are the two types of sweat glands?
eccrine and apocrine
The composition of the secretions of the eccrine glands is ________.
99% water, sodium chloride, trace amounts of wastes, and vitamin C
Apocrine glands, which begin to function at puberty under hormonal influence, seem to play little role in hermoregulation. Where would we find these glands in the human body?
in the palms of the hands and soles of the feet
The sebaceous glands are simple alveolar glands that secrete a substance known as sebum. The secretion of sebum is stimulated ________.
by hormones, especially androgens
In addition to protection (physical and chemical barrier), the skin serves other functions. Which of the following is another vital function of the skin?
It converts modified epidermal cholesterol to a vitamin D precursor important to calcium
metabolism.
Burns are devastating and debilitating because of loss of fluids and electrolytes from the body. How do physicians estimate the extent of burn damage associated with such dangerous
fluid loss
by using the "rule of nines"
What is the first threat to life from a massive third-degree burn
catastrophic fluid loss
Male pattern baldness has a genetic switch that turns on in response to ________.
male hormones
Eyebrow hairs are always shorter than hairs on your head because ________.
eyebrow follicles are only active for a few months
Cradle cap in infants is called ________.
seborrhea
The white crescent portion of the nail is called the ________.
lunula
The layer of the epidermis immediately under the stratum lucidum in thick skin is the stratum
granulosum
The ________ are the small muscles located in the dermis that cause goose bumps.
arrector pili
A summertime golden bronze tan may not be a tan at all; especially if the skin appears almost
metallic bronze, it may be the result of ________ disease.
addisons
The coarse hair of the eyebrows and scalp is called ________ hair.
terminal
________ burns injure the epidermis and the upper regions of the dermis
second-degree burns
________ are pigment-producing cells in the epidermis
Melanocytes
The only place you will find stratum ________ is in the skin that covers the palms, fingertips,
and soles of the feet.
lucidum
The dermis is composed of the reticular and ________ layers
papillary
Name the four kinds of sudoriferous glands
eccrine
2. apocrine
3. ceruminous
4. mammary