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ch. 14 psychadelics
Terms in this set (14)
psychedelics effects & examples
-alrer sensory processing in the brain
-causes perceptual disturbances, changes in thought processing, and depersonalization.
-LSD, psilocybin, mescaline, MDMA, pcp, ketamine
mixing of senses
-sounds may appear as visual images
-reccurance of symptoms weeks or months after an individual takes LSD
-rare in occurrence.
-DSM-5 hallucinogen persisting perception disorder.
factors considered for the classification
-how much loss of awareness they cause
-how dangerous they are
two major groups of psychadelics
-phantastica and deliriant are 2 major groups
-subgroups are indole and catechol
-drugs that have the same basic structure as serotonin
-lsd, psilocybin, dmt.
drugs that have the same basic catechol structure as norepinephrine and dopamine.
-mescaline, MDMA (ectasy/Molly)
-alter perceptions while allowing the user to remain in communication with the present world.
produce more mental confusion, greater clouding of conciousness, and loss of touch with reality.
LSD absoprtion and mechanism of action.
-absorbed rapidly through the GI track.
-microdosing on tongue.
-doesnt cross the bbb easily.
-tolerance develops rapidly within 3 -4 days of using
-recovery from tolerance is also rapid
-physical dependence hasn't been shown.
-acts by stimulating the serotonin 2a receptors.
-acts on dopamine, norepinephrine, glutamate.
-metabolized bu the liver, had life is about 3 hours.
effects of LSD
-effects start in 30 minutes and can last up to 12 hours
-first 20 mins: autonomic responses occur
-30-40 mins: alterations in mood, perception and sensation begin.
-within 1 hour: full intoxication begins.
-physical effects : dilated pupils, high body temp, increased hr, bp, sweating, tremors
-psychological: severe, terrifying thoughts, fear of losing control, fear of insanity and death.
absorption: rapid, doesn't cross bbb easily
metabolism: most excreted unchanged, half life is 6 hours, lasts up to 12 hours.
mechanism: acts on the synapse to increase the activity of dopamine, and norepinephrine, as well as small amounts of serotonin.
-low doses can euphoria, higher doses can cause full hallucinogenic effects.
-acts on the synapse to increase activity of dopamine, norepinephrine and high amounts of serotonin.
-schedule 1 drug.
-increases hr, bp
-increases euphoria, sociability
-heightens sense of closeness with others.
-jaw clenching, anxiety, paranoia, insomnia, dry mouth, increased body temp.
licensed as a medical use anesthetic for animals.
-causes toxic psychosis.
-blocks production of mucus in the nose and throat
-increase hr, eyes dilate, temperature increases, mouth is dry, perspiration stops, prevents salivation
-acts by binding selectively to the sigma receptor.
-other deliriants bind to the sigma receptor.
-acts on glutamate and opioid receptors.
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