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Intro to Mycology
Terms in this set (36)
T or F: Fungi are eukaryotic organisms meaning they have a true nucleus
Fungi has ____s ribosomes
Does fungi have their own mitochondria?
Yes they can generate their own energy
Enumerate the 3 complex carbohydrates in fungal cell wall
Major membrane sterol of fungi
MOA of Imidazole vs Polyene antifungals
Imidazole inhibits ergosterol synthesis
Polyene antifungal (Amph. B.) bind tightly to ergosterol breeching cell wall integrity
Mode of nutrition of fungi
Heterotrophic; they require organic carbon
T or F: fungi can photosynthesize like plants
FALSE they cant make their own food
Differentiate the purpose of SPORES in bacteria vs fungi
Bacteria: for survival
Fungi: for reproduction
Metabolism of fungi
Yeasts undergo _____ to multiply while Molds undergo _____
Yeast: budding (asymmetrical cell division)
Thermal dimorphism in fungi:
Becomes YEAST at ____deg C
Becomes MOLD at ____ deg C
Yeast: bodY temp = 37 degC
Mold: rooM temp = 25-30 degC
Death Cap mushrooms aka _____ cause ______ due to _____ and ______ content.
Amanitin and Phylloidin
Px ingested peanuts, seeds and grains contaminated with ______ causing her to develop liver cancer (hepatoma) because of what component of the fungi?
Inhalation of _______ spores result to allergic bronchopulmonary aspergillosis (IgE-mediated)
Aspergillus fumigatus spores
This dissolves human cells allowing visualization of fungal elements
Sabouraud's agar as (high/low) pH which inhibits bacterial growth
Predominant morphology of: coccidiomycoses (coccoides immitis)
Predominant morphology of: mycetoma
Predominant morphology of: Cryptococcosis
Yeasts with capsules
Predominant morphology of: Pneumocystitis
Cysts (asci) in pulmo specimens
T or F: Cause of Rose Gardener's disease is a dimorphic fungus
TRUE; Sporothrix schenckii
Inhaled microconidia of this fungi develop into budding yeast inside macrophages and spread to liver and spleen in patients with defective CMI.
*isipin mo capsule niya yung macrophage
Most common cause of meningoencephalitis in HIV patients
Exists as an encapsulation yeast
Cryptococcus neoformans is difficult to stain hence to visualize it we...
do negative staining via India Ink method
Angio-invasive mold that forms fungus ball in the lung cavities
*aspergilloma yung tawag sa sakit
Asthma symptoms with expectoration of brownish bronchial plugs secondary to aspergillus fumigatus infection.
Allergic Bronchopulmonary Aspergillosis (ABPA)
Mucormycosis causative agent/s
Rhizopus oryzae and Mucor spp.
Antifungal therapy is directed at ___ to minimize risk of adverse effects on human cells.
inhibiting structures unique to fungi
This antifungal drug inhibits demethylase enzyme thus inhibiting conversion of ___ to ____.
Lanosterol to Ergosterol
Terbinafine, Naftinifine and Amorolifine inhibit conversion of ___ to ___ by inhibiting this enzyme.
Squalene to Lanosterol
This drug inhibits the penultimate step during fungal reproduction and/or growth.
Terbinafine, naftinifine, Amorolifine
This anti-fungal drug inhibits mitosis by inhibiting microtubules
This antifungal drug act on the DNA level
vs. prophylaxis and common tx for Candida = Fluconazole
Cell wall synthesis
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