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Terms in this set (26)
What is the SNS receptor in the heart? What about PNS receptor?
SNS + B1
PNS + M2
What happens in the heart when beta-stimulation occurs?
increased contractility, Hr, and conduction speed
What is the SNS receptor in the arteries? What happens when stimulated?
alpha 1 > alpha 2
what happens when the PNS receptor in heart is stimulated?
Decreased contractility, Hr, conduction speed
What is the PNS receptor in the vasculature?
there is not one
What happens when beta-2 is stimulated in the myocardium?
What happens when beta-2 is stimulated in the skeletal muscle?
What happens when beta-2 is stimulated in the bronchial tree?
What happens when M3 is stimulated in the bronchial tree?
What happens with the renal tubules when alpha-2 is stimulated?
diuresis (ADH inhibition)
What happens with the renal tubules when beta-1 is stimulated?
increased renin release
What is the primary neurotransmitter in the SNS?
Where does NE get converted to Epi?
in the adrenal medulla
What is the rate limiting step in the conversion of NE to epi?
What is NE synthesized from?
tyrosine or phenylalanine (converted to tyrosine first)
What is the primary way that NE is removed from the synaptic cleft? What can block this process?
reuptake into the presynaptic nerve
reuptake is blocked by tricyclic antidepressants and cocaine
What is the end products of NE metabolism?
What are the principal sites of metabolism of catecholamines that have entered circulation (including IV administration)?
the kidneys and liver
What is the primary transmitter in the PNS?
Nicotinic receptors are ___ ___, while muscarinic receptors are ___ ___ ___
ion channels, linked to G-proteins
What are the 5 major components of the reflex arc?
sensor, afferent pathway, control center, efferent pathway, effector organ
remember ACE - afferent, control, efferent
The preganglionic neuron is a ____ while the postganglionic neuron is a ___
preganglionic = myleninated b-fiber
postganglionic= unmyelinated c-fiber
In the PNS a cholinergic postgalnglionic fiber releases what onto its effector organ?
In the SNS an adrenergic postganglionic fiber releases what onto its effector organ?
Where does the SNS originate?
Where does the PNS originate?
CN III, VII, IX, X
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