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27 terms

Chemo Drugs that Require Pre-medications / rescue agents

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Irinotecan
premedicate with atropine for diarrhea
treat with loperamide for diarrhea
5-FU
treat diarrhea with loperamide
treat myelosupression with G-CSF (filgrastin, pegfilgrastim)
treat thrombocytopenia with platelet transfusion, RBC transfusion, Epo stimulating agents (Darbepoetin, epoetin)
Hold ice chips in mouth and admin palifermin for stomatitis
Docletaxel
use prophylactic dexamethasone (steroids) for edema
Vincristine
use heat packs for extravasation reaction
Vinblastine
use heat packs for extravasation reaction
Vinerelbine
use heat packs for extravasation reaction
Doxorubicin
use cold compress for extravasation reaction
use dexrazoxane to prevent cardiotoxicity
Daunorubicin
use cold compress for extravasation reaction
use dexrazoxane to prevent cardiotoxicity
Epirubicin
use cold compress for extravasation reaction
Idararubacin
use cold compress for extravasation reaction
Mitomycin
use cold compress for extravasation reaction
premedicate with dexamethasone, phenothiazine (compazine), 5HT3 Rc antagonist, neurokinine 1 antagonist, for delayed acute CINV nausea and vomiting.
treat with corticosteroids for pulmonary toxicity
Paclitaxel
use cold compress for extravasation reaction

premedicate with ranitidine, diphenhydramine, dexamethasone for hypersensitivity reaction
Mechlormethamine
use cold compress for extravasation reaction
premedicate with dexamethasone, phenothiazine (compazine), 5HT3 Rc antagonist, neurokinine 1 antagonist, for delayed acute CINV nausea and vomiting.
Cyclophosphamide
premedicate with hydration and Mesna for hemorrhagic cystits
treat myelosupression with G-CSF (filgrastin, pegfilgrastim)
treat thrombocytopenia with platelet transfusion, RBC transfusion, Epo stimulating agents (Darbepoetin, epoetin)
premedicate with dexamethasone, phenothiazine (compazine), 5HT3 Rc antagonist, neurokinine 1 antagonist, for delayed acute CINV nausea and vomiting.
Ifosfamide
premedicate with hydration and Mesna for hemorrhagic cystits
premedicate with dexamethasone, phenothiazine (compazine), 5HT3 Rc antagonist, neurokinine 1 antagonist, for delayed acute CINV nausea and vomiting.
Asparaginase
premedicate with ranitidine, diphenhydramine, dexamethasone for hypersensitivity reaction
Cisplatin
premedicate with ranitidine, diphenhydramine, dexamethasone for hypersensitivity reaction
premedicate with dexamethasone, phenothiazine (compazine), 5HT3 Rc antagonist, neurokinine 1 antagonist, for delayed acute CINV nausea and vomiting.
premedicate with hydration therapy for renal toxicity
Carboplatin
premedicate with ranitidine, diphenhydramine, dexamethasone for hypersensitivity reaction
Etoposide
premedicate with ranitidine, diphenhydramine, dexamethasone for hypersensitivity reaction
Tenoposide
premedicate with ranitidine, diphenhydramine, dexamethasone for hypersensitivity reaction
Alkylating Agents
treat myelosupression with G-CSF (filgrastin, pegfilgrastim)
treat thrombocytopenia with platelet transfusion, RBC transfusion, Epo stimulating agents (Darbepoetin, epoetin)
Methotrexate
treat myelosupression with G-CSF (filgrastin, pegfilgrastim)
treat thrombocytopenia with platelet transfusion, RBC transfusion, Epo stimulating agents (Darbepoetin, epoetin)
Leucovorin rescue agent for too much of this drug which can cause megaloblastic anemia
premedicate with hydration therapy for renal toxicity
Hold ice chips in mouth and admin palifermin for stomatitis
Cytarabine
premedicate with dexamethasone, phenothiazine (compazine), 5HT3 Rc antagonist, neurokinine 1 antagonist, for delayed acute CINV nausea and vomiting.
Bleomycin
treat with corticosteroids for pulmonary toxicity
Busulfan
treat with corticosteroids for pulmonary toxicity
Traztuzumab
treat with corticosteroids for pulmonary toxicity
Streptozocin
premedicate with hydration therapy for renal toxicity