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Serotonin Pharmacology

Terms in this set (48)

L-Tryptophan combines with ___ to create L-5-Hydroxytryptophan (5-HTP). ___ is a co-factor
Tryptophan hydroxylase
Tatrahydrobiopterin
L-5-Hydroxytryptophan (5-HTP) combines with Aromatic L-amino acid decarboxylase to create ___
Serotonin (5-HT)
Serotonin (5-HT) combined with ___ yields 5-hydroxyindole acetic acid (5-HIAA)
MAO
Serotonin is found in enterochromaffin cells of ___, ___, and __. Where is it most abundant?
GI tract (80%)
platelets
CNS
Is tryptophan hydroxylase normally saturated?
No
Where does final synthesis of serotonin occur?
In the axon terminal
Unlike tyrosine hydroxylase, ___ is not regulated by end product inhibition; both enzymes are regulated by ___
tryptophan hydroxylase
phosphorylation
5-HT neurons have both isoforms of ___; ___ preferentially metabolizes 5-HT in brain; ___ principal isoform form in platelets
MAO
MAO-A
MAO-B
Serotonin is inactivated by ___
reuptake
5-HT membrane transporter same molecular family as ___ and ___ transporters and has same requirements
Dopamine
Norepinephrine
Almost all serotonergic neurons are found in what part of the Central nervous system (CNS)?
The Raphe nucleus
What are 7 functions of serotonin?
Emotion/Mood
Anxiety
Aggression
Sleep
Dominance hierarchies
Appetite and food consumption
Memory
Serotonin receptors are the largest ____
Family of receptors
How many families of serotonin receptors are there? How are they named?
7 different families
They are named 5-HT 1 through 5-HT 7
Which one is the only metabotropic serotonin receptor family?
5-HT 3
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