EXOTOXINS: a protein, larger chemical weight, boiling denatures (heat liable), can be toxoided, highly potent, extracellular secreted, high specificity, produced by gram positive bacteria (some g- bac) Highly antigenic, tissue specific, no fever produced.
ENDOTOXIN: Lipopolysacharide, smaller chemical weight, boiling does not denature (heat stable),can not be toxoided, low potency, outer cell membraine--not secreted, non specific, gram negative An endotoxin is a toxin shed from the outer membrane, and not actively secreted. poorly antigenic, non specific, produce fever.
*(Exos are proteins with a very strong specificity for a target cell and very strong, often deadly, effects. The exos affect cells by disrupting intracellular function and initiating lysis. There are many examples of exotoxins. However, by contrast, there is only one endotoxin. Endotoxins are actually chemicals called LPS (lipopolysaccharides) that are part of the outer cell membrane of Gram negative cell walls. G(-) bacteria release these lps molecules into tissues or into the circulation. Endotoxin causes fever, hemorrhage, and diarrhea. Blood infections by these bacteria cause endotoxic shock, which is fatal.)