Lost Colony of Roanoke Island
Sir Walter Raleigh hired John White to lead a group of settlers there that included woman and children. White sailed back to England to get supplies, but a war with Spain prevented him from returning for three years. When a rescue crew eventually arrived, the only thing they found was the word "Croatoan" carved into a tree. Four hundred years later, no one knows exactly what happened to the colony. All that is known is that the Croatoan Indians lived in the region. That is the only clue.