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14 terms

Diabetes Oral Drug/Insulin Doses

initial dosing, dose adjustments, brand names
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Metformin
Glucophage
500mg BID
Glimepiride
Amaryl
1-2 mg/day
Glipizide
Glucotrol
5 mg/day
Glyburide
Diabeta, Micronase
5 mg/day
Pioglitazone
Actos
15 mg/day
Rosiglitazone
Avandia
2 mg/day
Exenatide
Byetta
5 mcg BID
Sitagliptin
Januvia
100 mg/day
CrCL 30-50 (50 mg/day), CrCL <30 (25 mg/day)
Insulin total daily dose
0.5 - 0.6 mg/day
Insulin basal dose
40-50% (NPH, Glargine, Detemir, Lantus)
Insulin bolus dose
50 - 60% (Regular, Aspart, Lispro)
Insulin short acting switch to rapid acting
use 80% of short acting dose (decrease by 20%)
Insulin BASAL dose adjustment
only based on fasting glucose correction
50 / unit insulin (popl'n) or 1800 / total units insulin (indv)
Insulin BOLUS dose adjustment
decide based on prandial glucose
calculate based on fasting glucose and carb coverage
carbs: 12-15 / unit insulin (popl'n) or 450 / unit insulin (indv)