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TABLE 139-1 ANTIBACTERIAL AGENT(S) MECHANISM(S) OF ACTION

Terms in this set (27)

β-Lactams (penicillins, cephalosporins, monobactams, carbapenems)
Bind cell wall cross-linking enzymes (PBPs, transpeptidases)
Glycopeptides (vancomycin, teicoplanin, telavancin, dalbavancin, oritavancin)
Block cell wall glycosyltransferases by binding D-Ala-D-Ala stem-peptide terminus
Glycopeptides (vancomycin, teicoplanin, telavancin, dalbavancin, oritavancin)
Teicoplanin, telavancin, dalbavancin, and oritavancin: affect membrane function
Bacitracin
Blocks lipid carrier of cell wall precursors
Fosfomycin
Blocks linkage of stem peptide to NAG by enoyltransferase
Aminoglycosides (gentamicin, tobramycin, amikacin)
Bind 30S ribosomal subunit
Aminoglycosides (gentamicin, tobramycin, amikacin)
Block translocation of peptide chain
Aminoglycosides (gentamicin, tobramycin, amikacin)
Cause misreading of mRNA
Tetracyclines (tetracycline, doxycycline, minocycline)
Bind 30S ribosomal subunit Inhibit peptide elongation
Tigecycline
Same as tetracyclines
Macrolides (erythromycin, clarithromycin, azithromycin) and ketolide (telithromycin)
Bind 50S ribosomal subunit Block peptide chain exit
Lincosamides (clindamycin)
Bind 50S ribosomal subunit
Lincosamides (clindamycin)
Block peptide bond formation
Streptogramins (quinupristin, dalfopristin)
Same as macrolides
Chloramphenicol
Binds 50S ribosomal subunit
Sets found in the same folder