Hemoglobin and Myoglobin

True/False 2,3 BPG binds in gap between 2 beta chains
Click the card to flip 👆
1 / 21
Terms in this set (21)
True/False 2,3 BPG binds in gap between 2 beta chains
True
Hemoglobin affinity for oxygen decreases in anemia
True. In anemia, there is increased in 2,3 BPG which bind in gap between two beta chains and decreases affinity of Hemoglobin for oxygen
Why are people able to tolerate chronic anemia and remain asymptomatic ( no shortness of breath)
Increase in 2,3 BPG ensures increased delivery of oxygen to peripheral tissues and hence patient doesnot develop shortness of breath inspite of lower Hb
2,3 BPG has lower affinity for HbF than HbA
True
Carbon dioxide lowers the affinity of Hb for oxgyen
True ( explained by Bohr effect)
At physiological acidosis, the affinity of Hb for oxgen will decrease.
True.
An increase in hydrogen ion concentration stabilizes the deoxygenated conformation of the haemoglobin molecule, and so physiological acidosis leads to a reduction in the oxygen affinity
An increase in temperature reduces oxygen affinity
True. Increased temperature causes rightward shift of oxygen dissociation curve and stabilizes Hb in Taut form/deoxygenated form. Its important in exercising muscles.
Extreme hypothermia can cause decreased oxygen delivery to tissues
True. Decreased temperature shifts oxygen dissociation curve towards left and stabilizes Hb in relaxed form.
Hemoglobin changes from taut to relaxed form when oxygen binds ?
True. There are two forms of Hb- T form /Taut form/Deoxygenated form/Low affinity form
R form/Relaxed form/oxygenated form/high affinity form
Binding of one oxygen molecule to one heme group increases the affinity for oxygen of its other heme groups? True or False
True. Its known as phenomenon of positive coperativity
The binding of protons to HbA causes release of oxygen from HbA? True or FalseTrue- This is called as Bohr's effectBinding of 2,3-BPG to HbA decreases the affinity of HbA for oxygen?True.Hemoglobin has higher oxygen affinity at high pO2 in lungs and lower oxygen affinity at lower p02 in tissues , making it good transport protein. True or falseTrue. Hb is completely saturated /oxygenated in lung and it loses oxygen in peripheral tissues.Left shift of oxygen dissociation curve means an increased affinity for oxygen and increased oxygen loadingtrueBinding of 2,3 BPG,H ions, Carbon dioxide to Hb stabilizes T form and reduce the affinity of Hb for Oxygen ? True or falseTrue,Chronic hypoxia at high altitudes increases synthesis of 2,3 BPG and causes a right shift of oxygen dissociation curve? True/FalseTrueIn fever, increase in temperature decreased oxygen affinity and promotes oxygen unloading from HbTrueDecreased 2, 3 BPG, hypothermia, alkalosis, Fetal Hb increase oxygen affinity of Hb?True. These factors cause a left shift of oxygen dissociation curveCarbon monoxide & MetHb decrease oxygen saturation of the bloodTrue, Carbon monoxide displaces the oxygen from Hb ( it binds to same site as oxygen)and thus decreases oxygen saturation. Hb and myoglobin have 200 times more affinity for carbon monoxide than oxygen.Heme is present in hydrophobic pocket of globin chains? True/FalseTrueRappaport leubering shunt creates 2,3 BPG in RBC?True