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pharmaco 5
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Geriatric Pharmacology
- liver (capacity of the liver to extract drug from the
blood based on hepatic blood flow)
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Drug clearance
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Terms in this set (56)
Geriatric Pharmacology
- liver (capacity of the liver to extract drug from the
blood based on hepatic blood flow)
Drug clearance
Geriatric Pharmacology
• Decreased function of phase ? reactions (CYP450)
Minimal changes in phase II reactions
• Decreased ? due to impaired liver blood flow
• Decreased function of phase I reactions (CYP450)
Minimal changes in phase II reactions
• Decreased metabolism due to impaired liver blood flow
less blood flow to liver in older ppl corresponds to
increased extension of half life
geriatrics have altered
? and
Impaired ? responses (examples)
• Cardiac output
• Postural hypotension
• Temperature regulation
• Fasting blood glucose
pharmacokinetics and
Impaired homeostatic responses (examples)
• Cardiac output
• Postural hypotension
• Temperature regulation
• Fasting blood glucose
Geriatric Pharmacology
• Increase in number of drugs = increase in ?
• ? with number of meds
• Increase in number of drugs = increase in ADRs
• ADRs with number of meds