Mechanism: In pharmacologic doses, suppresses inflammation and the normal immune response.
Suppresses adrenal function at chronic doses of 0.75 mg/day. Has negligible mineralocorticoid activity.
Uses: Used systemically and locally in a wide variety of chronic diseases including: Inflammatory, Allergic, Hematologic, Endocrine, Neoplastic, Dermatologic, Autoimmune disorders, Management of cerebral edema, Diagnostic agent in adrenal disorders. Unlabeled Use(s): Adjunctive management of nausea and vomiting from chemotherapy.
Toxicity: PEPTIC ULCERATION, THROMBOEMBOLISM
Mechanism: androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US.
Uses: Methyltestosterone is an anabolic steroid hormone used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause.
Toxicity: Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation
Mechanism: A synthetic analogue of luteinizing hormone-releasing hormone (LHRH). Initially causes a transient increase in testosterone; however, with continuous administration, testosterone levels are decreased. Reduces gonadotropins, testosterone, and estradiol
Uses: Advanced prostate cancer in patients who are unable to tolerate orchiectomy or estrogen therapy (may be used in combination with flutamide or bicalutamide). Central precocious puberty (CPP). Endometriosis. Uterine fibroids (with iron therapy).
Toxicity: SEIZURES, STROKE, MYOCARDIAL INFARCTION, PULMONARY EMBOLI, QT INTERVAL PROLONGATION, HEPATOTOXICITY, GI BLEEDING