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51 terms

CHAPTER 16

STUDY
PLAY
The scientist who received the first Nobel Prize in medicine for his work on antibody therapy was
VON BEHRING
Proteins that react specifically with the chemical structures in the antigen that induces them are called
ANTIBODIES
Antibodies are made by
BCELLS AND PLASMA CELLS
T cells primarily are responsible
CELL-MEDIATED IMMUNITY
Secondary lymphoid organs
are strategically located in the body AND facilitate interactions between cells
Epitopes or antigenic determinants
are a portion of antigen recognized by antibody AND may be approx. 10-25 amino acids in length
The humoral immune response involves the manufacture and use of
ANTIBODIES
Which of the following is not typical of an antigen
LOW MOLECULAR WEIGHT
Specific chemical groups on an antigen molecule to which the immune response is directed are
ANTIGENTIC DETERMINANTS
Generally antigenic molecules usually have molecular weight greater than
10,000 DALTONS
Which of the following is/are secondary lymphoid organ(s)?
SPLEEN AND LYMOH NODES
A term synonymous with antibody is
IMMUNOGLOBIN
Which of the following do not induce a strong immune response
LIPIDS AND NUCLEIC ACIDS
There are __ classes of antibody
5
Which of the following antibodies is a pentamer?
IGM
The chains of an antibody molecule are bonded to one another by
DISULFIDE BONDS
Which of the following antibodies is a dimmer?
IGA
The immunoglobulin monomer conists of
2 HEAVY AND 2 LIGHT CHAINS
Which class of antibody accounts for the bulk of the circulating antibody
IGG
The characteristic function and properties of each class of antibody is determined by the
CONSTANT REGION AND HEAVY CHAIN
An IgG molecule has two
HEAVY CHAINS, LIGHT CHAINS & ANTIGEN BINDING SITES
Antigens interact with antibodies at
AT THE OUTER END OF EACH ARM OF Y
The Fc region on IgG
INTERACTS W THE COMPLEMENT
How long after initiation of a primary response do significant amounts of antibody appear in the blood?
10-14 DAYS
The only class of antibody that can cross the placenta is
IGG
Which is the first antibody class made during the primary response to an antigen?
IGM
Which of the following is the most abundant immunological class produced?
IGA
Which is the most efficient at intitating the classical pathway of the complement cascade?
IGM
Which of the following class of antibody is primarily found in external secretions?
IGA
The function of the secretory component of the IgA molecule is
to protectc IGA from being destroyed by proteolytic enzymes.
The immunoglobulin that is important in hypersensitivity reactions is
IGE
According to the clonal selection theory
EACH B CELL IS ALREADY PROGRAMMED TO PRODUCE A CERTAIN ANTIBODY
"Clonal selection" and "clonal expansions"
ALL OF THE ABOVE
Tcells and B cells are manufactured in the
BONE MARROW
T cells mature in the
THYMUS
The cells that actually secrete antibodies are
PLASMA CELLS
CD4 cells are often
T HELPER CELLS
CD8 cells are often
T CYTOTOXIC CELLS
Antigens may be processed for presentation by
MACROPHAGES & DENDRITIC CELLS
Macrophages and dendritic cells are
ANTIGEN PRESENTING CELLS
Only antigen presenting cell
PRODUCE MHC CLASS II MOLECULES
It would be useful if antigens were delivered directly to
PEYERS PATCHES & MCELLS
Class II MHC molecules are found primarily on
MACROPHAGES & DENDRITIC CELLS
The stimulation of B cells to divide and mature is provided by T
T HELPER CELLS
peptides presented by MHC class II peptide molecules are
EXOGENUS ANTIGENS
T-independent antigens
POLYSACCHARIDES
The surface receptors on B and T cells both
VARIABLE & CONSTANT REGION
Which is involved in reacting to virus -infected cells?
Cell-mediated immunity, Tcytoxic cells AND MHC I
Perforin is produced by
NK CELLS
Giant cells are
USED TO CONTAIN BACTERIAL INFECTIONS
Apoptosis is a
form of cell suicide AND is induced in target cells by effector T cytotoxic cells.