Heme degradation and Jaundice -1

Production of Heme occurs in Reticuloendothelial system ( RES)
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Terms in this set (16)
Unconjugated bilirubin binds to albumin through covalent bondsFalse. There are two types of binding sites on albumin- High affinity sites ( which bind bilirubin noncovalently and tightly) Low affinity sites ( which bind bilirubin non covalently and loosely)Bilirubin monoglucuronide and Bilirubin diglucuronide are water soluble forms of bilirubin.True. These are two forms of conjugated bilirubin which is water soluble.Secretion of conjugated bilirubin into bile is an active process- mediated by ATP dependent transporter MRP2.True. MRP2 also known as multidrug resistant protein & is member of MOAT ( Multiple organic anion transporter)Urobilinogen is reduced to sterobilinogen by gut bacteria which forms stercobilin. The stercobilin is responsible for color of stoolTrueUrobilin is responsibile for color of urineTrueFate of urobilinogen in intestine - explainMost of urobilinogen ( UBG) is reduced to stercobilinogen which is excreted in feces, Some of it enters enterohepatic circulation and is reexcreted in bile. A small amount of UBG reaches kidneys and is excreted in urine either as such or after oxidation to yellow urobilin which is responsible for yellow color of urine.