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18 terms

PTH and etc

zoo331
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hypercalcemia
too much calcium; deposit into bones or excrete
with hypercalcemia, PTH and calcitonin
pth decreases, calcitonin increases
what happens to threshold and ap with hypercalcemia?
increases threshold making it harder for AP's
hypocalcemia
too little calcium; increase PTH (osteoclasts degrade bone)
calcitonin
stimulates osteoblasts to put Ca in bone
what secretes PTH?
parathyroid
how does pth increase blood calcium levels?
bone resorption, kidney resorption, vit D increases absorption
vitamin D activates
liver and kidney
sun on skin makes which vit D?
hydroxycholecalciferol
decreased Ca-->PTH makes what form of vitamin D in the kidneys?
calcitriol (dihydroxy)
2 direct targets of pth?
kidney and bone
GH cascade
hypothal (ghrh), ant pit (gh), liver (igf)
IGF
inhibits ghrh, stim ghih; inhibits gh
gluticorticoids
decrease bone formation, increase breakdown
estradiol
decreases apoptosis, decreases osteoclast
testosterone
increases bone formation, inhibits resorption
decrease plasma Ca/promote bone deposition
calcitonin, gh, igf, sex hormones
increases plasma Ca/promote resorption
PTH, vitamin D (dihydroxy), cortisol