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Terms in this set (59)

1. Allergic Effect: immune system response that occurs when the body misinterprets the drug as a foreign substance and forms antibodies against the drug
- Can happen immediately after administration or be delayed for hours, days, weeks, etc.
- Symptoms can increase in severity each time the drug is administered
- Common symptoms → rash, urticaria, diarrhea, fever, nausea, vomiting

2. Anaphylactic reaction/Anaphylaxis: more serious, life threatening allergic reaction characterized by respiratory distress, sudden bronchospasm, and cardiovascular collapse
- Treated with vasopressors, bronchodilators, corticosteroids, O2 therapy, IV fluids, antihistamines

3. Drug Tolerance: when the body becomes accustomed to the effects of a drug over a period of time; larger doses needed to produce the same effects
Ex: morphine → when used consistently for a long period of time, the body will become tolerant to the therapeutic effects therefore person would need a higher dose of the drug to control their pain


4. Toxic Effect: specific groups of symptoms related to drug therapy that carry risk for permanent damage or death
Can be caused by:
Cumulative effect → body cannot metabolize one dose of a drug fully before another dose is given
- Drug is taken in more frequently than it is excreted leading to an increase in concentration in the body
- Older adults at risk for this due to altered hepatic metabolism and decreased renal clearance/excretion

5. Idiosyncratic Effect: "paradoxical effect"; an unusual response to a drug; either an over-response, under-response, or the opposite of the expected response