# Chapter 9 - Alterations in immunity and Inflammation

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Hypersensitivity is best defined as a(an):
a. Disturbance in the immunologic tolerance of self-antigens
b. Immunologic reaction of one person to the tissue of another person
c. Altered immunologic response to an antigen that results in disease
d. Undetectable immune response in the presence of antigens
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Terms in this set (42)
ANS: A
Type I reactions are mediated by antigen-specific IgE and the products of tissue mast cells
(see Figure 9-1). The most common allergies (e.g., pollen allergies) are type I reactions. In
addition, most type I reactions occur against environmental antigens and are therefore
allergic. The other options do not accurately identify the mediation factor related to hay
fever
During an IgE-mediated hypersensitivity reaction, what causes bronchospasm?
a. Bronchial edema caused by the chemotactic factor of anaphylaxis
b. Bronchial edema caused by binding of the cytotropic antibody
c. Smooth muscle contraction caused by histamine bound to H1 receptors
d. Smooth muscle contraction caused by histamine bound to H2 receptors
What is the mechanism that results in type II hypersensitivity reactions?
a. Antibodies coat mast cells by binding to receptors that signal its degranulation,
followed by a discharge of preformed mediators.
b. Antibodies bind to soluble antigens that were released into body fluids, and the
immune complexes are then deposited in the tissues.
c. Cytotoxic T lymphocytes or lymphokine-producing helper T 1 cells directly attack
and destroy cellular targets.
d. Antibodies bind to the antigens on the cell surface.
ANS: D
The mechanism that results in a type II hypersensitivity reaction begins with antibody
binding to tissue-specific antigens or antigens that have attached to particular tissues. The
cell can be destroyed by antibody IgG or IgM and activation of the complement cascade
through the classical pathway.