Med Chem I - Final Exam

This medication affects the storage and release of NE - and is historically used as a remedy for snake bites as well as a sedative.

A) Vesamicol
B) Hemicholinium
C) Botulinum Toxin
D) Reserpine
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This medication affects the storage and release of NE - and is historically used as a remedy for snake bites as well as a sedative.

A) Vesamicol
B) Hemicholinium
C) Botulinum Toxin
D) Reserpine
D) Reserpine
Image: This medication affects the storage and release of NE - and is historically used as a remedy for snake bites as well as a sedative. A) Vesamicol B) Hemicholinium C) Botulinum Toxin D) Reserpine
What is the order of potency of these substances for alpha adrenoreceptors?

- Norepinephrine
- Epinephrine
- Isoproterenol
Epinephrine > Norepinephrine > Isoproterenol

Opposite of beta order.
What is the order of potency of these substances for beta adrenoreceptors?

- Norepinephrine
- Epinephrine
- Isoproterenol
Isoproterenol > Norepinephrine > Epinephrine

Opposite of alpha order.
In the metabolism of Norepinephrine - Monoamine Oxidase (MAO) likes to...

A) Oxidation of the amine group (NH2) to an aldehyde (CHO)
B) Removal of the *OH* on the aromatic ring
C) Addition of a methyl group to the *aromatic OH*
D) Oxidize aldehyde (CHO) to a carboxylic acid
E) Reduce aldehyde (CHO) group to OH
F) B and C only
A) Oxidation of the amine group (NH2) to an aldehyde (CHO)
Image: In the metabolism of Norepinephrine - Monoamine Oxidase (MAO) likes to... A) Oxidation of the amine group (NH2) to an aldehyde (CHO) B) Removal of the *OH* on the aromatic ring C) Addition of a methyl group to the *aromatic OH* D) Oxidize aldehyde (CHO) to a carboxylic acid E) Reduce aldehyde (CHO) group to OH F) B and C only
In the metabolism of Norepinephrine - Aldehyde Dehydrogenase (AD) likes to...

A) Oxidation of the amine group (NH2) to an aldehyde (CHO)
B) Removal of the *OH* on the aromatic ring
C) Addition of a methyl group to the *aromatic OH*
D) Oxidize aldehyde (CHO) to a carboxylic acid
E) Reduce aldehyde (CHO) group to OH
F) B and C only
D) Oxidize aldehyde (CHO) to a carboxylic acid
Image: In the metabolism of Norepinephrine - Aldehyde Dehydrogenase (AD) likes to... A) Oxidation of the amine group (NH2) to an aldehyde (CHO) B) Removal of the *OH* on the aromatic ring C) Addition of a methyl group to the *aromatic OH* D) Oxidize aldehyde (CHO) to a carboxylic acid E) Reduce aldehyde (CHO) group to OH F) B and C only
In the metabolism of Norepinephrine - Catechol-O-Methyl Transferase (COMT) likes to...

A) Oxidation of the amine group (NH2) to an aldehyde (CHO)
B) Removal of the *OH* on the aromatic ring
C) Addition of a methyl group to the *aromatic OH*
D) Oxidize aldehyde (CHO) to a carboxylic acid
E) Reduce aldehyde (CHO) group to OH
F) B and C only
C) Addition of a methyl group to the *aromatic OH*

Like the name says!
Image: In the metabolism of Norepinephrine - Catechol-O-Methyl Transferase (COMT) likes to... A) Oxidation of the amine group (NH2) to an aldehyde (CHO) B) Removal of the *OH* on the aromatic ring C) Addition of a methyl group to the *aromatic OH* D) Oxidize aldehyde (CHO) to a carboxylic acid E) Reduce aldehyde (CHO) group to OH F) B and C only
In the metabolism of Norepinephrine - Aldehyde Reductase (AR) likes to...

A) Oxidation of the amine group (NH2) to an aldehyde (CHO)
B) Removal of the *OH* on the aromatic ring
C) Addition of a methyl group to the *aromatic OH*
D) Oxidize aldehyde (CHO) to a carboxylic acid
E) Reduce aldehyde (CHO) group to OH
F) B and C only
E) Reduce aldehyde (CHO) group to OH
Image: In the metabolism of Norepinephrine - Aldehyde Reductase (AR) likes to... A) Oxidation of the amine group (NH2) to an aldehyde (CHO) B) Removal of the *OH* on the aromatic ring C) Addition of a methyl group to the *aromatic OH* D) Oxidize aldehyde (CHO) to a carboxylic acid E) Reduce aldehyde (CHO) group to OH F) B and C only
This medication prevents the transportation of synthesized ACh in the cytoplasm into the storage vesicles by "carrier B."

A) Vesamicol
B) Hemicholinium
C) Botulinum Toxin
D) Reserpine
A) Vesamicol

It sounds like "vesicle."
This medication prevents the release of ACh through interaction with the neuronal membrane synaptobrevin proteins. It also approved to treat muscle spasms.

A) Vesamicol
B) Hemicholinium
C) Botulinum Toxin
D) Reserpine
C) Botulinum Toxin
This medication blocks the reuptake of choline by high affinity choline reuptake transporters

A) Vesamicol
B) Hemicholinium
C) Botulinum Toxin
D) Reserpine
B) Hemicholinium
GABAa receptors are... A) GPCRs B) Ligand-gated ion channelsB) Ligand-gated ion channelsGABAb receptors are... A) GPCRs B) Ligand-gated ion channelsA) GPCRsThis medication can be used to help block MPTP induced Parkinsonism by *blocking the enzyme MAO-B.* A) Paraquat B) Alphapronidine C) Rasagiline D) Meperidine E) KumquatC) RasagilineMuscarinic receptors are... A) GPCRs B) Ligand-gated ion channelsA) GPCRsNicotinic receptors are... A) GPCRs B) Ligand-gated ion channelsB) Ligand-gated ion channelsThis medication is an antagonist for Nicotinic muscle type receptors (Nm). A) Mecamylamine B) Trimetaphan C) Hexamethonioum D) Tubocurarine E) A, B, and C onlyD) TubocurarineThis medication is an antagonist for Nicotinic ganglionic type receptors (Nn). A) Mecamylamine B) Trimetaphan C) Hexamethonioum D) Tubocurarine E) A, B, and C onlyE) A, B, and C onlyIn adrenergic phenylethanolamine agonists - increasing the size of the group at this site will increase the drug's activity at beta receptors. A) R1 B) R2 C) R3 D) All of the aboveA) R1This medication is an open ring analog of clonidine used for its antihypertensive effects. A) Apraclonidine B) Brimonidine C) Guanfacine D) Guanabenz E) A and B only F) C and D onlyF) C and D onlyWhich one of these medication is a 2-*Aryl*imidazoline a₁-agonist? A) Clonidine B) Alfuzosin C) Phenylephrine D) OxymetazolineD) OxymetazolineWhich one of these medication is a 2-*Amino*imidazoline a₂-agonist? A) Clonidine B) Alfuzosin C) Phenylephrine D) OxymetazolineA) Clonidine (& friends)What is the rate-limiting step in Acetylcholine synthesis?Active uptake of choline into the neuron. *Hemicholiniums would block ACh synthesis at this point.*What is the rate-limiting step in Norepinephrine synthesis?Conversion of Tyrosine to DOPA via Tyrosine Hydroxylase. The first step in the synthesis she wants us to draw.This site on AChE serves to bind a molecule of ACh to the enzyme. A) Anionic site B) Esteratic siteA) Anionic siteThis site on AChE is where the hydrolytic reaction occurs after ACh is bound. A) Anionic site B) Esteratic siteB) Esteratic siteWhat does Ing's "rule of five" have to say about chain length in regards to muscarinic potency?Ing's rule suggests that there should be no more than five attoms between the nitrogen and terminal hydrogen atom for *maximal* muscarinic potency.Which one of these direct acting cholinergic agonists is most useful for the diagnosis of asthma via inhalation? A) Carcachol Chloride B) Methacholine Chloride C) Bethanechol ChlorideB) Methacholine ChlorideWhich one of these direct acting cholinergic agonists is most useful for the treatment of postsurgical urinary retention and abdominal distension? A) Carcachol Chloride B) Methacholine Chloride C) Bethanechol ChlorideC) Bethanechol ChlorideWhich one of these direct acting cholinergic agonists is most useful for the treatment of glaucoma and the induction of miosis? A) Carcachol Chloride B) Methacholine Chloride C) Bethanechol ChlorideA) Carcachol ChlorideWhich one of these should be used as an *antidote* for *acute Pilocarpine poisoning?* A) Atropine B) Muscarine C) Scopolamine D) Physostigmine E) BethanecholA) Atropine Via Slide 9 of Alzheimer's LectureWhich one of these medications is often used for treatment of motion sickness, iritis, and parkinsonism? A) Atropine B) Muscarine C) Scopolamine D) Physostigmine E) BethanecholC) ScopolamineThis medication is used as a *reversible* inhibitor of Acetylcholinesterase. A) Atropine B) Muscarine C) Scopolamine D) Physostigmine E) BethanecholD) Physostigmine