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5 Written questions

5 Matching questions

  1. Blastomyces dermatitidis Diagnosis
  2. Mechanism of Dimorphic Switch
  3. Paracoccidioides brasiliensis Morphology
  4. Blastomyces dermatitidis Reservoir
  5. Coccidioides immitis Morphology
  1. a 1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic
  2. b 1. The shift from mold to yeast involves induction of the heat shock response and uncoupling of oxidative phosphorylation
    2. This is followed by shutdown of RNA synthesis
    3. The cells then pass through a metabolically inactive phase
    4. The metabolism in the yeast phase shifts to sulfhydryl compounds
    5. This is reversible and is one of the major virulence factors of these organisms
  3. c Dimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  4. d 1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  5. e 1. Mississippi river valley extending north to the great lakes
    2. Resides in soil or rotten wood
    3. Respiratory transmission

5 Multiple choice questions

  1. 1. "Valley Fever"
    A. malaise, cough, chest pain, fever, arthralgias
    B. lasts 2-6 wks
    C. chest xray is clear or has hilar adenopathy
    D. resolution is spontaneous 90%
    2. Dissemination
    A. skin, bone, meninges
    B. MENINGITIS (fever, headache, stiff neck)
    C. Risks:
    -African or Filipino ancestry
    -Men
    -Pregnant women
    -T-cell number / functional abnormalities
  2. 1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss
  3. 1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)
  4. Coccidioidomycosis aka "Valley Fever"
    1. Asymptomatic (in most persons)
    2. Pneumonia
    3. Disseminated (<1%): can affect the LUNGS, SKIN, BONES, & MENINGES

    Note: a small percentage of individuals with this infection will develop painful erythematous nodular lesions called erythema nodosum
  5. 1. Mississippi valley
    2. Present in bird and bat droppings
    3. Respiratory transmission

5 True/False questions

  1. Paracoccidioides brasiliensis Treatment1. Central and S. America
    2. Brazil

          

  2. Coccidioides immitis Reservoir1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission

          

  3. Coccidioides immitis TreatmentOnly for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)

          

  4. Paracoccidioides brasiliensis Pathogenesis & Clinical disease1. The conidia are inhaled and are usually contained and cleared
    2. Chronic disease with pulmonary and/or lymph node involvement
    3. If a person develops pulmonary infection, they develop cough, fever, malaise, weight loss
    4. Can also affect mucous membranes of the mouth, larynx

          

  5. Histoplasma capsulatum MorphologyDimorphic:
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
    3. NO Capsule 9despite name)
    4. Grow in macrophages