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5 Written questions

5 Matching questions

  1. Paracoccidioides brasiliensis Pathogenesis & Clinical disease
  2. Paracoccidioides brasiliensis Treatment
  3. Blastomyces dermatitidis Treatment
  4. Coccidioides immitis Reservoir
  5. Histoplasma capsilatum Treatment
  1. a 1. The conidia are inhaled and are usually contained and cleared
    2. Chronic disease with pulmonary and/or lymph node involvement
    3. If a person develops pulmonary infection, they develop cough, fever, malaise, weight loss
    4. Can also affect mucous membranes of the mouth, larynx
  2. b 1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission
  3. c 1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)
  4. d 1. trimethoprim/sulfamethoxazole (TMP sulfa): 1st choice
    2. itraconazole and amphotericin B
  5. e 1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)

5 Multiple choice questions

  1. 1. Central and S. America
    2. Brazil
  2. 1. The main control of this organism is by cell mediated immunity
    -Mainly the T-cell activation of macrophages

    2. Neither B cells or antibody have a significant role
  3. 1. Mississippi river valley extending north to the great lakes
    2. Resides in soil or rotten wood
    3. Respiratory transmission
  4. 1. Life long immunity does develop
    2. Conidia can be phagocytosed and killed by PMNs
    3. The endospores cannot be handled until macrophages are activated by T-cells (Th1)
    4. Humoral immunity does not play a role
    5. Complement is not effective at opsonizing C. immitis
  5. 1. Mississippi valley
    2. Present in bird and bat droppings
    3. Respiratory transmission

5 True/False questions

  1. Paracoccidioides brasiliensis Morphology1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C

          

  2. Blastomyces dermatitidis Immunity1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic

          

  3. Coccidioides immitis MorphologyDimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C

          

  4. Paracoccidioides brasiliensis Diagnosis1. Diagnosis is made by seeing the yeast with multiple blastoconidia (think of a ship's steering wheel)
    2. Measurement of antibodies have a 95% sensitivity

          

  5. Histoplasma capsilatum Clinical DiseaseHISTOPLASMOSIS
    1. Asymptomatic (in most persons)
    2. Pneumonia: lesions calcify, which can be seen on chest x-ray (may look similar to tuberculosis)
    3. Disseminated: can occur in almost any organ, especially the LUNG, SPLEEN, LIVER