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5 Written questions

5 Matching questions

  1. Histoplasma capsilatum Treatment
  2. Histoplasma capsilatum Immunity
  3. Coccidioides immitis Clinical Symptoms
  4. Coccidioides immitis Reservoir
  5. Histoplasma capsulatum Reservoir
  1. a 1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission
  2. b 1. The main control of this organism is by cell mediated immunity
    -Mainly the T-cell activation of macrophages

    2. Neither B cells or antibody have a significant role
  3. c 1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)
  4. d 1. "Valley Fever"
    A. malaise, cough, chest pain, fever, arthralgias
    B. lasts 2-6 wks
    C. chest xray is clear or has hilar adenopathy
    D. resolution is spontaneous 90%
    2. Dissemination
    A. skin, bone, meninges
    B. MENINGITIS (fever, headache, stiff neck)
    C. Risks:
    -African or Filipino ancestry
    -Men
    -Pregnant women
    -T-cell number / functional abnormalities
  5. e 1. Mississippi valley
    2. Present in bird and bat droppings
    3. Respiratory transmission

5 Multiple choice questions

  1. 1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic
  2. 1. trimethoprim/sulfamethoxazole (TMP sulfa): 1st choice
    2. itraconazole and amphotericin B
  3. 1. Lung biopsy
    A. Silver stain specimen
    B. Culture on Sabouraud's agar will reveal hyphae at 25 C, and yeast at 37 C
    2. Serology
    3. Skin test (tests for exposure only)
  4. Only for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)
  5. 1. Conidia are inhaled and reach the alveoli
    2. The conidia then convert to yeasts
    3. Survive by capturing iron and calcium from the macrophage
    4. Grow within macrophages
    5. Granulomatous inflammation similar to TB (cell-mediated immunity)

5 True/False questions

  1. Coccidioides immitis MorphologyDimorphic
    1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C

          

  2. Paracoccidioides brasiliensis Clinical Symptoms1. "Valley Fever"
    A. malaise, cough, chest pain, fever, arthralgias
    B. lasts 2-6 wks
    C. chest xray is clear or has hilar adenopathy
    D. resolution is spontaneous 90%
    2. Dissemination
    A. skin, bone, meninges
    B. MENINGITIS (fever, headache, stiff neck)
    C. Risks:
    -African or Filipino ancestry
    -Men
    -Pregnant women
    -T-cell number / functional abnormalities

          

  3. Coccidioides immitis Disease1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission

          

  4. Blastomyces dermatitidis Treatment1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)

          

  5. Bastomyces dermatitidis Morphology1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic