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5 Written questions

5 Matching questions

  1. Coccidioides immitis Clinical Symptoms
  2. Blastomyces dermatitidis Diagnosis
  3. Histoplasma capsilatum Clinical Symptoms
  4. Blastomyces dermatitidis Immunity
  5. Bastomyces dermatitidis Disease
  1. a 1. "Valley Fever"
    A. malaise, cough, chest pain, fever, arthralgias
    B. lasts 2-6 wks
    C. chest xray is clear or has hilar adenopathy
    D. resolution is spontaneous 90%
    2. Dissemination
    A. skin, bone, meninges
    B. MENINGITIS (fever, headache, stiff neck)
    C. Risks:
    -African or Filipino ancestry
    -Men
    -Pregnant women
    -T-cell number / functional abnormalities
  2. b 1. fevers, sweats, weight loss
    2. in disseminated disease, skin & subcutaneous nodules and mucous membrane ulcerations are not unusual (tongue, larynx)
  3. c Blastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers
  4. d 1. Not clear what the predominant host response is
    2. Complement, antibody and cell mediated immunity are all involved
  5. e 1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic

5 Multiple choice questions

  1. 1. Mississippi river valley extending north to the great lakes
    2. Resides in soil or rotten wood
    3. Respiratory transmission
  2. 1. Diagnosis is made by seeing the yeast with multiple blastoconidia (think of a ship's steering wheel)
    2. Measurement of antibodies have a 95% sensitivity
  3. 1. Central and S. America
    2. Brazil
  4. 1. The conidia are inhaled and are usually contained and cleared
    2. Chronic disease with pulmonary and/or lymph node involvement
    3. If a person develops pulmonary infection, they develop cough, fever, malaise, weight loss
    4. Can also affect mucous membranes of the mouth, larynx
  5. 1. Conidia are inhaled
    2. Once inside host, the conidia change into spherules due to increased temp, lower pH and interactions with phagocytes
    3. The spherule is a "sac" of endospores which are released and lead to new spherules
    4. Proteases released by the spherule are virulence factors
    5. They destroy collagen, elastin and immunoglobulins

5 True/False questions

  1. Coccidioides immitis Reservoir1. Desert areas of the southwestern US & northern Mexico
    2. Respiratory transmission

          

  2. Bastomyces dermatitidis Morphology1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C

          

  3. Blastomyces dermatitidis Pathogenesis1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic

          

  4. Paracoccidioides brasiliensis Clinical Symptoms1. "Valley Fever"
    A. malaise, cough, chest pain, fever, arthralgias
    B. lasts 2-6 wks
    C. chest xray is clear or has hilar adenopathy
    D. resolution is spontaneous 90%
    2. Dissemination
    A. skin, bone, meninges
    B. MENINGITIS (fever, headache, stiff neck)
    C. Risks:
    -African or Filipino ancestry
    -Men
    -Pregnant women
    -T-cell number / functional abnormalities

          

  5. Histoplasma capsilatum Immunity1. The main control of this organism is by cell mediated immunity
    -Mainly the T-cell activation of macrophages

    2. Neither B cells or antibody have a significant role

          

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