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5 Written questions

5 Matching questions

  1. Blastomyces dermatitidis Treatment
  2. Coccidioides immitis Treatment
  3. Paracoccidioides brasiliensis Clinical Symptoms
  4. Bastomyces dermatitidis Morphology
  5. Histoplasma capsilatum Clinical Symptoms
  1. a 1. Pulmonary Infection
    2. Cough
    3. Fever
    4. Malaise
    5. Weight loss
  2. b 1. Mycelial forms with spores at 25 C
    2. Yeast forms at 37 C
  3. c 1. fevers, sweats, weight loss
    2. in disseminated disease, skin & subcutaneous nodules and mucous membrane ulcerations are not unusual (tongue, larynx)
  4. d Only for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)
  5. e 1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)

5 Multiple choice questions

  1. 1. Not clear what the predominant host response is
    2. Complement, antibody and cell mediated immunity are all involved
  2. 1. Itraconazole
    2. Amphotericin B (in immunocompromised patients)
  3. 1. Life long immunity does develop
    2. Conidia can be phagocytosed and killed by PMNs
    3. The endospores cannot be handled until macrophages are activated by T-cells (Th1)
    4. Humoral immunity does not play a role
    5. Complement is not effective at opsonizing C. immitis
  4. Blastomycosis
    1. Asymptomatic (uncommon)
    2. Pneumonia: lesions rarely calcify (most common)
    3. Disseminated (uncommon): present with weight loss, night sweats, lung involvement, and skin ulcers
    4. Cutaneous: skin ulcers
  5. 1. trimethoprim/sulfamethoxazole (TMP sulfa): 1st choice
    2. itraconazole and amphotericin B

5 True/False questions

  1. Blastomyces dermatitidis Reservoir1. Itraconazole (1st choice)
    2. Amphotericin B (2nd choice)

          

  2. Blastomyces dermatitidis Diagnosis1. Biopsy of affected tissue: lung, skin, etc
    A. silver stain specimen
    B. culture on Sabouraud's agar
    2. Serology
    3. Skin tests (tests for exposure only)

    *For skin infections, direct demonstration of the yeast with broad based budding is diagnostic

          

  3. Histoplasma capsulatum Reservoir1. Lung biopsy
    A. Silver stain specimen
    B. Culture on Sabouraud's agar will reveal hyphae at 25 C, and yeast at 37 C
    2. Serology
    3. Skin test (tests for exposure only)

          

  4. Coccidioides immitis MorphologyOnly for disseminated:
    1. Fluconazole (1st choice)
    2. Ampothericin B (2nd choice)

          

  5. Paracoccidioides brasiliensis Morphology1. trimethoprim/sulfamethoxazole (TMP sulfa): 1st choice
    2. itraconazole and amphotericin B