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decreased hemoglobin/hematocrit below nl range for age and gender. disease manifestation. not final diagnosis.
4 Response to Anemia
(1) inc HR (2) vasoconstriction (3) salt retention (3) inc 2,3 DPG (4) inc erythoproietin synthesis
importance of reticulocyte count
if pt is making new RBCs will see high reticulocyte account (rules out dec RBC proliferation)
retic index < 2% or absolute retic count < 75,000
suggests problem with RBC production. hypoproliferative abnormality
Retic index > 2% or absolute retic count > 100,000
shows good marrow response to anemia. suggests hemorrhage or hemolysis
causes of Microcytic Anemia
Thalassemia, anemia of chronic disease, iron deficiency, lead poisoning, sideroblastic anemia
most common. marrow isnt working well or mixed or acute problem. ex acute blood loss.
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