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IP-Asthma drugs

Terms in this set (70)

What is the generic name for Advair Diskus
fluticasone/salmeterol (ICS+LABA)
What is the generic name for Advair HFA
Fluticasone/salmeterol (ICS+LABA)
What is the generic name for AirDuo RespiClick
Fluticasone/salmeterol (ICS+LABA)
What is the generic name for Alvesco HFA
Ciclesonide (ICS)
What is the generic name for ArmonAir Digihaler
Fluticasone propionate (ICS)
What is the generic name for Arunity Ellipta
Fluticasone furoate (ICS)
What is the generic name for Asmanex Twisthaler
Mometasone (ICS)
What is the generic name for Asmanex HFA
Mometasone (ICS)
What is the generic name for Breo Ellipta
Fluticasone furoate/vilanterol (ICS+LABA)
What is the generic name for Dulera HFA
Mometasone/formoterol (ICS+LABA)
What is the generic name for Flovent Diskus
Fluticasone propionate (ICS)
What is the generic name for Flovent HFA
Fluticasone propionate (ICS)
What is the generic name for Pulmicort Flexhaler
Budesonide (ICS)
What is the generic name for Pulmicort Respules
Budesonide (ICS)
What is the generic name for Qvar RediHaler
Beclomethasone HFA (ICS)
What is the generic name for Symbicort HFA
Budesonide/formoterol (ICS+LABA)
What is a medium dose of Beclomethasone for ages 12 and up?
>200-400 mcg
What is a low dose of Beclomethasone for ages 12 and up?
100-200 mcg
What is a high dose of Beclomethasone for ages 12 and up?
>400 mcg
What is a low dose of Budesonide for ages 12 and up?
200-400 mcg
What is a medium dose of Budesonide for ages 12 and up?
>400-800 mcg
What is a high dose of Budesonide for ages 12 and up?
>800 mcg
What is a medium dose of Fluticasone furoate for ages 12 and up?
100 mcg
What is a low dose of Fluticasone furoate for ages 12 and up?
100 mcg
What is a high dose of Fluticasone furoate for ages 12 and up?
200 mcg
What is a low dose of Fluticasone propionate for ages 12 and up?
100-250 mcg
What is a medium dose of Fluticasone propionate for ages 12 and up?
>250-500 mcg
What is a high dose of Fluticasone propionate for ages 12 and up?
>500 mcg
What is a medium dose of Beclomethasone for ages 6-11?
>100-200 mcg
What is a low dose of Beclomethasone for ages 6-11?
50-100 mcg
What is a high dose of Beclomethasone for ages 6-11?
>200 mcg
What is a low dose of Budesonide for ages 6-11?
100-200 mcg
What is a medium dose of Budesonide for ages 6-11?
>200-400 mcg
What is a high dose of Budesonide for ages 6-11?
>400 mcg
What is a low dose of Fluticasone furoate for ages 6-11?
50 mcg
What is a medium dose of Fluticasone furoate for ages 6-11?
50 mcg
What is a high dose of Fluticasone furoate for ages 6-11?
no high dose for this
What is a low dose of Fluticasone propionate for ages 6-11?
50-100 mcg
What is a medium dose of Fluticasone propionate for ages 6-11?
>100-200 mcg
What is a high dose of Fluticasone propionate for ages 6-11?
>200 mcg
Bronchial smooth muscle
Methylxanthines Site of action
Inhibits phosphodiesterase (PDE) and increases cAMP
Methylxanthines Mechanism of action
Bronchodilation: Prevents and treats wheezing, shortness of breath, and chest tightness.
Methylxanthines Benefit
Bronchiole smooth muscle & mast cells
b2 agonist Sites of Action
Agonist binds to GCPR which activates AC and that turns ATP into cAMP which leads to Bronchiole smooth muscle relaxation and Inhibit mast cell degranulation
b2 agonist Pharmacological mechanism
-Bronchiole smooth muscle relaxation --> Bronchodilation
-Inhibit mast cell degranulation
• prevent release of leukotrienes
• reduce mucus secretion by goblet cells
b2 agonist Pharmacological benefit:
Bronchiole smooth muscle & goblet cells
Muscarinic antagonists Sites of Action
This prevents ACH from binding to the GCPR which prevents Ca release
Muscarinic antagonists Pharmacological mechanism
block M3 receptors:
Prevent bronchiole smooth muscle constriction
Reduce mucus secretion from goblet cells
reducing release of intracellular Ca2+ stores
Muscarinic antagonists Pharmacological benefit:
which drug type reducing inflammation, vascular leakage, mucus secretion, and promoting bronchodilataion
corticosteroid therapy
What type of drug is Omalizumab (Xolair)
Monoclonal antibodies
Serum/lung tissue
Site of action for Omalizumab (Xolair)
Monoclonal antibody binds free IgE
Mechanism of Action for Omalizumab (Xolair)
- Mast cell stabilizers-reduce mast cell degranulation and release of mediators.
- Used in asthma with allergic rhinitis.
Pharmacological Effect/benefit for Omalizumab (Xolair)
-Immune cells with IL-4 and IL-13 receptors (B cells, eosinophils, macrophages)
Site of action for Dupliumab
Monoclonal antibody that inhibits IL-4 and IL-13 signaling by binding to IL-4 receptor alpha
Mechanism of Action for Dupliumab
Limits overreaction of immune system.
Pharmacological Effect/benefit for Dupliumab
moderate to severe asthma with atopic dermatitis
Therapeutic use Dupliumab
eosinophil
Site of action for Benralizumab
monoclonal antibody binds IL-5 receptor
Mechanism of Action for Benralizumab
Reduces eosinophilic inflammation
Pharmacological Effect/benefit for Benralizumab
Eosinophilic Asthma
Therapeutic use Benralizumab
Mast Cells & eosinophils
Zileuton Site of Action
Inhibit 5- lipoxygenase enzyme, reducing synthesis of leukotrienes
Zileuton Pharmacological mechanism:
Reduce mucus, inflammation, bronchoconstriction and eosinophil recruitment
Zileuton, Montelukast & Zafirlukast Pharmacological Benefit
Bronchial smooth muscle, goblet cells, eosinophils
Montelukast & Zafirlukast Site of Action
Antagonize the CysLTR1
Montelukast & Zafirlukast Pharmacological mechanism
Increase both anti-inflamatory and mineralcorticoid activity
-17 alpha - OH
-9 alpha-F
-9 alpha - CL
-21 OH
Anti-inflammatory activity is increased
1-dehydro
- 6 alpha -F
-11 beta- OH
Mineralocorticoid activity decreased
-6 alpha - Ch3
-16 alpha, 17 alpha acetonide
-16 alpha - OH
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