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Drugs to Normalize Cholesterol

Terms in this set (13)

Lis the medications under HMG-CoA inhibitors (end in statin)
Atorvastatin, Lovastatin, Pravastatin, and Simvastatin
List the other drugs for CAD:
Ezetimibe, Fibrates; gemfibrozil, and fenofibrate; Niacin
What is the action for HMG-CoA inhibitors?
-Treatment and prevention for CAD
-Reduces LDL cholesterol lvl, reduces total cholesterol lvl
-Increases HDL cholesterol lvl
-Can lower triglyceride lvl

-Promotes plaque stability, reduce inflammation at plaque site, slow progression of CAD, improve ability of vasodilation all which reduce risk of thrombosis or cardiac event
What is the side effect of HMG-CoA inhibitors?
More common: headache, rash, and GI disturbances
Serious: liver damage, myopathy, and rhabdomyolosis
What are some nursing consideration of HMG-CoA inhibitors?
-Most effective when given in the evening
- Therapy is life long
- No grapefruit/grapefruit juice during treatment
-Report frequent muscle aches
What is the action of Ezetimibe?
- inhibits absorption of dietary cholesterol
- reduces total cholesterol, LDL, and triglycerides
What are the side effects of Ezetimibe?
Small risk of myopathy, liver impairment, and pancreatitis
What are some nursing considerations of Ezetimibe?
Often combined with a statin
What is the action of Fibrates?
reduces high levels of triglyceride
What are the side effects of Fibrates?
-increased risk of gallstones
-myopathy
-liver injury
-rash
-GI upset
What are the nursing considerations of Fibrates?
-increase concentration of warfarin
-monitor INR closely
What is the action of Niacin?
-reduces LDL and triglycerides
-increases HDL
What is the side effect of Niacin?
Severe flushing and serious hepatotoxicity
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