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Genetics of Cancer-Genetics Final
Terms in this set (36)
who coined the term, cancer?
substances that cuase cancer
what is the most common form of carcinogen?
mutagen (DNA damage)
group of diseases caused by loss of control
abnormal mass of body tissue, the growth of which exceeds and is uncoordinated with the normal tissues
a non-specific term meaning lump or swelling; can be malignant or benign
any malignant neoplasm/tumor
discontinuous spread of a malignant neoplasm to distant sites
tumor of epithelial
tumor of connective tissue
tumor of lymphatic tissue
tumor of glial cells
tumor of hematopoietic organs
process by which normal cells are transformed into cancer cells
what are the causes of cancer?
2. random spontaneous mutations
3. inherited germline mutations
4. infectious agents (viral, HPV, HepC)
these mutations occur sporadically in somatic cells, cancer susceptibility not passed on to offspring
cancer susceptibility passed on to offspring, usually requires second somatic mutation
which is more common, sporatic or inherited cancers?
what % of cancer is inherited?
what are the 4 major classes of cancer genes?
2. tumor suppressor genes
3. DNA repair genes
normal versions of genes that promote cell division
in mutated form, proto-oncogenes are called?
when proto-oncogene, Myc, is placed close to enhancer region of an antibody
which chromosome translocation is associated with Burkitt lymphoma?
chromosome 8 and 14
when are oncogenes activated?
when a proto-oncogene moves next to another gene and the pair is transcribed together
activates or lifts control of cell divison
what translocation is associated with acute promyelocytic leukemia?
translocation between chromosomes 15 and 17
combination of retinoic acid cell surface receptor and an oncogene, pml
acute promyelocytic leukemia
translocation between chromosome 9 and 22
chronic myeloid leukemia (CML)
tyrosine kinase that excessively stimulates cell division in chronic myeloid leukemia
genes that stop a cell from dividing
tumor suppressor genes
do both copies of the tumor suppressor gene have to be mutated in order for cell division to occur?
inheritance of Li-Fraumeni Syndrome?
autosomal DOMINANT germline mutation of p53
primary tumors associated with germline mutations in p53?
breast and colon carcinomas
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