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81 terms

Pharmacology chapter 4

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What is MDI
Metered dose inhaler
What are two of the most common aerosol devices for delivery of drugs
Nebulizer MDI/DPI
COPD patients have poor ---------due to Narrowed airways and obstruction
Distribution
A smokers lung has poor ------- due to narrowing or constriction because of no straight route for meds.
Penetration
Wy does inhalation route provide a fast onset of action
It goes directly to target
Three goals of inspired nation
Humidify gas,improve mobilization and elimination of secretions,deliver meds to respiratory tract
What is a suspension of solid or liquid particles within a gas
Aerosol
What process of delivery is for therapeutic purposes.
Aerosol therapy
The speed of delivery for medicine is called
Inertia inpaction
What tm refers to tendency of aerosol to remain in suspension
Stability
What is the best breathing pattern for aerosol delivery
Inspiratory hold
How far into the lungs medicine travels is
Penetration
What are three orientations
Person time place
Whatvare the spacers with one way valve that holds aerosol until patient inhales
Holding chambers
SVN
Small volume nebulizer
SPAG
SmAll particle aerosol generator
Where should 1-5 microns be deposited
Alveoli
Where should 5-10 microns be deposited
Central airways
Where should greater than 10 microns be deposited
Nose
Where should greater than 15 microns be deposited
Mouth
Three reasons for aerosol delivery
Humidity,remove sputum,deliver aerosolized drugs
Delivery methods
Vaporizer,nebulizer,inhaler,MDI,PDI,atomizer
Three dry powder inhalers
Spinhaler,rotahaler,turbinate,handihaler-spiriva
What are the air sacs that are receptor sights
Alveoli
What is the process of particles depositing out of suspension to remain in the lung
Deposition
What is goal of pharmacology respiratory care
To maintain open airways through three mechanisms of action
What are three mechanisms of action for RC Pharmacology
Relax bronchial smooth muscle,control or reduce secretions,reduce or prevent airwAy mucosal adema (swelling)
What is systemic affect
All over
What is local affect
One area
Three types of preparation for drugs
Solid liquid gas
What is desired vrate of onset
How quickly you want it to work (extended release)
Aftr PDI or MDI what must be done
Rinse mouth
Betters to use a nebulizer
Can't follow instructions,poor inspiration capacity, can't hold breath,unstable breathing pattern
DPI is better for
Poor hand breath coordination,accurate close monitoring
MDI is better
Can follow instructions,has good inspiratory capacity,can hold breath,
Nebulizer is better
Can aerosolize any drug solution, can modify dose, not necessary to hold,
What are the variables that affect aerosol deposition in the lung
Physical properties(weight),pattern of inhalation,temp in humidity,status of lung condition(past damage)
What are five components (parts) of MDI
Drug,propellant mixture, actuator,canister,metering valve
SPAG
Small particle aerosol generator
SVN
Small volume nebulizer
Upd
Updraft
Hhn
Hand held nebulizer
What is particle size for aerosol therapeutic application
1-10 microns
Mechanics of depositing
Inertia,gravitational,brownian
Patterns of inhalation
Lung volumes,inspiratory time,flow rates,mouth vs nose breathing,maneuvers (inspirational hold)
DPI
Necessary to have high inspiratory rate
spiriva
An example of DPI
3-4 mL
Optimal level for nebulizer
Deposition
Particle falling out into lungs
MDI
Provide a adequate inspiration dose
Spacer
Decreases oral phalangeal loss
Alveoli
Where is 10 sec inspirational old necessary
Brownian movement
Less than 1 waste
Gravitational settling
Down to 1
Inertial expansion
5-10
Elevated eosinophils elevated
Allergy asthma
Stridor
Abnormal high pitched musical sound
Pleural friction rub
Sound of rubbing usually where pain is
Wheezing
An obstruction
Ronchi
Crackling sounds during inspiration
Biots
CNS disorder with periods of apnea irregular breathing
Lethargic
Responds when arroused
Obtunded
Wakes with difficulty then responds
Stuperous
Doesnt wake completely decreased mental and physical
Spacer
What item would you use to decrease Ora phalangeal loss
Less than 1
What is waste on brownian movement
Down to 1
What is waste on gravitational
5-10
What is waste on inertia expansion
Alveoli
Where does the substance go in a 10 second hold
MDI
In order to get an adequate hold what would you use
Deposition
Process of particle falling out into lungs
3-4 ml
Optimal level for nebulizer
Hand washing
Most important way to prevent contact transmission of microorganisms
Vehicle transmission
Transmission of microorganisms by way ofbinanimate objects
Droplet transmission
A form of contact transmission by dropletsvlargervthan 0.5 micrometers
Airborne transmission
Transmission of microorganismsbby way of air currents
Contact transmission
Direct transmission of microorganisms by physicalbcontact between one person and anoth
Spinnaker albuterol Budesonide handihaler-spiriva
Drugs for dpi
Noscomial infection
What' is a hospital acquired infections
Cross-contamination
Transmission of organisms between people and places
DPI
This is used for high inspiratory flow rates