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Drugs for Hyperthyroidism and Hypothyroidism
Terms in this set (14)
What are the medications for Hyperthyrodism?
-Methimazole (1st line drug)
-Propylthiouracil (2nd line drug) (multiple daily dose)
-Radioactive Iodine (treatment of choice for non-pregnant adults)
-Nonradioactive Iodine (lugol's solution)
What is the action for Methimazole and PTU?
-suppress synthesis of thyroid hormones
-can be long term
-used short term for surgery prep
What are the SE for Methimazole and PTU?
-Rare: methimazole can cause agranulocytosis (decreased WBC, increased infection risk) Stop medication: fever (low grade), sore throat.
-PTU can cause severe liver injury, agranulocytosis (rash)
What are NC for Methimazole and PTU?
-Methimazole is safer and more convenient than PTU and is preferred
-May take 3-12 weeks to be effective, but improvements within 2-3 weeks.
-Can only be used during 2nd and 3rd trimesters of pregnancy. Not 1st trimester.
-PTU is preferred for 1st trimester of pregnancy and for clients who are experiencing a thyroid storm
-Monitor for WBC, and liver function
What is the action for Radioactive Iodine?
-destroys thyroid tissue
- Only 1 dose
What are the SE of Radioactive Iodine?
-may cause delayed hypothyroidism, and carries a slight risk of caner in pediatric clients
What are the NC for Radioactive Iodine?
-Take 2-3 months to take effect
-Effects of treatment are delayed, should not be used in children, or during pregnancy or breastfeeding
-use radioactive precaution
What is the action of Nonradioactive Iodine (Lugol's solution)?
-inhibits thyroid hormone synthesis and inhibits the release of thyroid hormones into the blood
-suppresses thyroid function before surgery
-short term only
What are the SE for Nonradioactive Iodine (Lugol's solution)?
-chronic ingestion can cause iodism and overdoes causes injury to the GI tract
What are NC for Nonradioactive Iodine (Lugol's solution)?
-Lugol's solution: Mix with juice to mask the taste.
-Decrease GI upset
-Can stain teeth, use a straw
What is the medication for Hypothyroidism?
What is the action of levothyroxine (sindroide)?
-replaces deficient thyroxine (T4)
-uses with all pt with hypo
What are the SE for levothyroxine (sindroide)?
-when appropriate dosage is used, SE are rare (homeostasis)
-Chronic overtreatment can cause atrial fibrillation and bone loss (in older adults)
-With acute overdose, thyrotoxicosis may result: tachycardia, insomnia, hyperthermia, and sweating
What are the NC for levothyroxine (sindroide)?
-life long therapy
-narrow therapeutic range: blood levels should be monitored, and clients should not switch from one brand to another
-should be taken on an empty stomach 30-60 minutes before eating, in the AM, because food decreases absorption
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