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Signs of infection
-slow-wave sleep induction (lots of sleep but no rest)
-classic signs of inflammation (redness, swelling, heat and pain)
Goal of Antibiotic therapy
Decrease the population of the invading bacteria to a point where the human immune system can effectively deal with the invader
-identification of the causative organism
-based on the culture report, an antibiotic is chosen that has been known to be effective at treating the invading organism
bacteria and resistance to antibiotics
-adapt to their environment
-the longer an antibiotic has been in use, the greater the chance that the bacteria will develop into a resistant strain
A group of powerful antibiotics used to treat serious infections caused by gram-negative aerobic bacilli;
IV or IM
Tobramycin (eye drops): for bacterial conjuctivitis and corneal abrasions
Aminoglycosides - adverse effects
Ototoxicity and nephrotoxicity are the most significant; will worsen with diuretics and neuromuscular blockers
-prototype: Ertapenem (Invanz)
-indications: community acquired pnemonia and complicated GU infections
-IV or IM route
cephalosporins - pharmacokinetics
-well absorbed from the GI tract
-metabolized in the liver, excreted in the urine
Fluoroquinolones - indications
treating infections caused by susceptible strains of gram-negative bacteria. Includes urinary tract, respiratory tract and skin infections
Fluoroquinolones - actions
interferes with DNA replication in susceptible gram-negative bacteria, preventing cell reproduction
Fluoroquinolones - Pharmacokinetics
-absorbed in the GI tract
-metabolized in the liver
-excreted in urine and feces
Fluoroquinolones - contraindications
-known allergy, pregnancy, or lactating women; seizures and renal dysfunction
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