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6.1 GASTROINTESTINAL DRUGS
Terms in this set (50)
H. pylori infection and NSAIDs
2 main causes of Peptic ulcers
Mainstay treatment for ulcers thr advent of PPIS and H2 antagonists.
Interact with gastric acids at cellular level to neutralize them.
MOA of antacids
Common adverse effect of magnesium hydroxide
Common adverse effect of aluminum htdroxide
Antacid that causes metabolic alkalosis
Ant vid that causes systemic alkalosis
Prevent histamine from binding to its receptor in the parietal cells blocking the release of HCL acid in the stomach in response to gastrin.
MOA of H2 antagonists
H2 antagonists that causes gynecomastia
Irreversibly inhibit the gastric parietal cell proton pump, H/K ATPase. Blocks the final common pathway of acid secretion the proton pump.
MOA of PPIs
Possible increased risk of hip, spine, and wrist fractures
Risk with use of PPIs in old patients
Mucosal protective agents
Agents that coat any injured area in the stomach to prevent further injury from acid.
Aluminum sucrose sulfate
Sucralfate is short for...
Mucosal protective Agent
Sacralfate drug classification
In water or acidic solution, it binds selectively to erosions for up to
6h→forms physical barrier.
MOA of sucralfate
Prostaglandin analog used in pud
SE of misoprostol
Black stool anf tongue
SE of bismuth salicylate
Prostanoic acid used in chronic constipation
Bile Salt-Binding Resins: cholestyramine and cholestipol
Clinical uses: Diarrhea caused by excess fecal bile acids (seen in
Crohn's disease of terminal ileum). (2)
MOA: similar to somatostatin → lower gastric secretion and motility.
local irritant that increases intestinal mobility
Agar, Psyllium seed, Methylcellulose, Bran
Bulk Forming Laxatives (4)
Mineral oil, Glycerin suppositories, Docusate
Stool softeners (3)
BALANCED POLYETHYLENE GLYCOL
Used for complete colonic cleansing prior to GI endoscopic procedures
. Ingested rapidly (4L over 2-4 hours)
Irritable bowel syndrome
Idiopathic chronic, relapsing disorder characterized by abdominal
discomfort (pain, bloating, distention, or cramps) in association with alterations in bowel habits (diarrhea, constipation or both)
Serotonin receptor-4 antagonist
Tegaserod drug class
Serotonin 5-HT3 Receptor Antagonist
1st generation anti-histamine also used with other antiemetics for treatment of emesis due to chemotherapy
Hyosine is also known as...
Serotonin 5-HT3 inhibitors
ONDANSETRON, GRANISETRON, AND DOLASETRON are...
Costocostetouds that Enhance the efficacy of 5-HT3-receptor (2)antagonists
Purine analogs: Azathioprine and 6-mercaptopurine
For induction and maintenance of remission of ulcerative colitis
and Crohn's disease (2)
Induce and maintain remission in Crohn's disease
Somatostatin and Octreotide
Used for Initial hemostasis from bleeding esophageal varices
Vasopressin and Terlipressin
Causes splanchnic arterial vasoconstriction leading to reduced
splanchnic perfusion and lowered portal venous pressure
Reduce portal venous pressure via a decrease in portal venous
inflow due to decrease in CO (B1 blockade) and splanchnic
vasoconstriction (B2 blockade)
Lipase inhibitor used to treat obesity
The acid neutralization effect of antacids lasts for how many hours?
H2 blocker that has a bioavailability of almost 100%
Colloidal bismuth compounds
This group of drugs is used in nonspecific dyspepsia or acute
What is the cholinomimetic drug that is used for stimulating GI motility for patients with Ogilvie's syndrome?
stimulant laxative that is clinically used as local irritant that increases intestinal mobility.
A laxative that can impair fat soluble vitamins when used in long term.
What is the classification of drugs that inhibit muscarinic cholinergic receptors in the enteric plexus and smooth muscle?
Where can you find the vomiting center in the brain that receives input from the CTZ?
H1 antihistamine that only has minimal anticholinergic properties?
Classification of drugs that are initially used in initiation of chemotherapy to reduce vomiting caused by anxiety.
First line treatment for ulcerative colitis to induce and maintain remission.
It is used for the dissolution of small cholesterol gallstone with symptomatic gallbladder disease.
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