12 terms

# Posology

Med math and pharmacology
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Posology
Study of doses
Dose
the amount of drug given to an animal to give a certain effect
Dosage
is the amount of drug per unit body weight (kilograms or pound) and is usually mg/kg or mg/lb
Types of doses
1. Therapeutic (effective) dose
2. Toxic dose
3. Lethal dose
Minimal Therapeutic
dose
is the smallest amount that has a therapeutic effect
Maximal therapeutic dose
is the largest amount that can be tolerated without producing toxic effects
Therapeutic dose
is the optimal dose, which lies some place between the minimal and maximal therapeutic doses
effective dose fifty
(ED50)
is the effective dose in 50% of the animals
Toxic dose
the amount that produces undesirable clinical, hematological, biochemical or pathological alterations
Lethal dose
the dose that causes death
lethal dose fifty
(LD50)
the dose that causes death in 50% of the animals
Therapeutic index
therapeutic ratio
is the ratio between the LD50 and ED50
the larger the therapeutic index the wider the margin of safety of the drug