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NSAIDs - 8
Terms in this set (49)
NSAIDs act by inhibiting
PGs are stored in cells & tissues
Release of PGs is dependent on
Which COX is constitutively expressed & more associated with normal physiologic functions?
Which COX is inducible by cytokines & associated with inflammation?
NSAIDs do not inhibit
What may be involved in aspirin hypersensitivity?
overproduction of leukotrienes
COX1 produces ______ which causes platelet aggregation
COX2 is associated with production of PGI2 which is
cardioprotective (inhibition has detrimental effect with respect to CV system)
What plays a role in inflammation & bronchoconstriction?
What are the therapeutic effects of NSAIDs?
analgesic, antipyretic (decrease fever), anti-inflammatory
Why do we administer NSAIDs to neonates?
induce closing of ductus arteriosus
What is the most prominent side effect of acetaminophen?
What results from vasoconstriction due to NSAID administration?
renal toxicity (contract afferent arteriole and decrease GFR)
Most common side effect of NSAIDs
What is the mechanism leading to gastric damage?
inhibition of PGE2
Which NSAID does not tend to cause GI effects?
Disturbances in platelet function result from
decreased formation of TXA2 leading to increased bleeding time (no clotting)
Which drugs are preferred for patients with GI ulcers?
COX2 selective inhibitors
What should be avoided in patients with bleeding disorders?
aspirin & other COX1 inhibitors
Aspirin ____________ COX enzymes which blocks PG synthesis
Which NSAID is the only irreversible inhibitor?
What is used to treat inflammation, fever, & pain?
acetylsalicylic acid (aspirin)
Aspirin inhibits platelet aggregation for
the life of the platelet
Side effects specific to Aspirin include
GI ulceration, tinnitus (hearing loss), prolonged bleeding time
What may result in children infected with chicken pox that take Aspirin?
The therapeutic actions of acetaminophen include
analgesic & antipyretic actions
The drug of choice for fever & pain
Acetaminophen, unlike Aspirin, is not useful for
Unlike aspirin, acetaminophen does not produce
gastric irritation or increased bleeding time
Upon overdosing on acetaminophen, what intermediate is formed that binds GSH?
If a patient presents with acetaminophen overdose, they should be given
sulfhydryl compounds to restore glutathione N-acetylcysteine
Most over the counter preparations of aspirin or acetaminophen contain addition compounds
What is combined with NSAIDs for moderate pain relief & to reduce exposure?
Which NSAIDs are propionic acid derivatives?
ibuprofen, naproxen, oxaproxin
Which propionic acid derivative has a long half life nearing 40 hours?
One of the most potent inhibitors of COX1/2 that is frequently used to close ductus arteriosus in newborns?
Potent analgesic recommended for short term use for severe pain?
a potent inhibitor of COX1 but has more COX2 activity
What has been formulated to gather to form Arthrotec to provide gastric protection?
diclofenac & misoprostol
A popular form of transdermal diclofenac (gel) & is often used to treat osteoarthritis?
anti-inflammatory, analgesic, and antipyretic; long half-life nearing 50 hours (single daily dose)
selective COX2 inhibitor although it will inhibit COX1, target inflammation, single daily dose
Administration of NSAIDs & glucocorticoids will increase
Administration of NSAIDs with diuretic agents will
decrease natriuretic and diuretic effects
Administration of NSAIDs with alcohol will
increased GI & hepatic effects
selective COX2 inhibitor
Celebrex has protection ______ risk due to inhibition of PGI2 production
Celecoxib has less
GI ulceration & antiplatelet effect
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