Genomics

What is the study of heredity and the variation of inherited characteristics?
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Terms in this set (18)
What is the study of heredity and the variation of inherited characteristics?
genetics
What is the field of genetics that attempt to understand the content, organization, function, and evolution of genetic information contained within and between whole genomes?
genomics
What is constructed from recombination frequencies in units of centimorgans?
genetic map
What are banding patterns based on chromosome staining?
cytological maps
What are molecular distance in base pairs, kilobases, and megabases? These often show restriction enzyme recognition sites, locations of particular clones, etc.
Physical Maps
What map shows an overlapping set of clones that give a physical map of part of a chromosome?
contig
What are the dates of the human genome project?
1991-2003
There are two approaches to genome sequences. Which is described below?
make a genomic library, fingerprint library and orient clones relative to each other. screen the library with markers that allow you to relate it to the recombinant map
map-based
There are two approaches to genome sequencing. Which is described below?
small-insert clones (plasmids) prepared directly from genomic data and sequenced, computer programs assemble by examining overlap, advantage of being highly automated.
whole genome shotgun approach
The final sequence of this type is created by putting together the sequences of the large clones and filling in any gaps
map-based
The entire genomic sequence is assembled by powerful computer programs in this typewhole genome shotgun approachThis is a specific site in the genome where the DNA base varies in at least 1% of the population.SNPsSNPs located near each other in the genome are often inherited together and can often be grouped as a _______haplotypeWhat is a sequence of SNP patterns along the length of a chromosome?haplotypeWhat is a widely prescribed anti-coagulant with greater than 10-fold inter-individual variability in the dose required to attain a therapeutic response.WarfarinHow do you control/regulate the spread of use of your genetic information? Is the information going to make life simpler or more complex? Who has access to your genetic information? These questions are all...ethical questions regarding genomicsWhat does GINA stand for?Genetic Information Nondiscrimination ActHealth insurance companies cannot decrease coverage or increase rates based on results of genetic test as a result of this act? Also that employers cannot discriminate based on the results.GINA