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Terms in this set (31)
Which of the following is NOT a reason for the selective toxicity of sulfa drugs?
Sulfa drugs cause production of antimetabolites. (They do not cause production of antimetabolites)
Which of the following statements is true about superinfections?
They may be caused by antibiotic-resistant bacteria.
Polyenes, azoles, and allylamines interfere with
fungal cell membranes
Bacterial infections are easier to treat using chemotherapy than are other types of infections caused by other types of microorganisms. Why?
Bacteria are prokaryotic and thus, have targets different than eukaryotic cells.
Rifampin blocks RNA polymerase and therefore inhibits
While observing the results of a disk-diffusion susceptibility test, you note an enlarged oval zone of inhibition around two adjacent antibiotic disks. Which of the following is the most likely explanation?
The two antibiotics are synergistic.
What is the benefit of combining penicillins with potassium clavulanate (clavulanic acid)?
It inhibits penicillinase.
You have a 200-milligram-per-milliliter antibiotic solution. You prepare serial dilutions (1:2, 1:4, etc.) of the antibiotic. You then inoculate each tube with Salmonella. Bacteria grow in tubes 4, 5, and 6. You subculture bacteria from tubes 1 through 3 to nutrient broth. Growth occurs in tubes 2 through 3. What is the MBC (minimum bactericidal concentration)?
You have a 200-milligram-per-milliliter antibiotic solution. You prepare serial dilutions (1:2, 1:4, etc.) of the antibiotic. You then inoculate each tube with Salmonella. Bacteria grow in tubes 4, 5, and 6. What is the MBC (minimum bactericidal concentration)?
The MBC cannot be determined from the information provided.
Which of the following is NOT a mechanism by which antibiotic resistance spreads horizontally among bacteria?
Ethambutol inhibits incorporation of mycolic acid into cell walls; therefore, it is effective against
Which of the following is a broad-spectrum, topical antibacterial compound?
What is the method of action of nucleoside analogs?
inhibition of DNA synthesis
A drug that binds with sterols would injure __________.
eukaryotic plasma membranes
Which of the following statements about antibiotics is true?
Most of our antibiotics are produced by Streptomyces, a genus of filamentous soil bacteria.
Clindamycin binds to the 50S ribosomal subunit to inhibit translocation. This antibiotic stops
translation in prokaryotes
Which of the following is an antihelminthic drug that causes paralysis of the worm?
A drug that inhibits peptidoglycan synthesis is
A chemical that kills gram-positive bacteria and gram-negative bacteria would best be described as
A disk-diffusion test identifies
agents to which a test culture is sensitive, in terms of growth or survival
Antibiotics are substances that inhibit other microorganisms and are produced by bacteria and fungi.
What is the mechanism of the resistance of MRSA to methicillin?
alteration of the target molecule
Which antibiotic inhibits replication?
The mode of action for erythromycin is
inhibition of protein synthesis
Because antifungal drugs such as amphotericin B target sterols in the plasma membrane, they are ineffective as antibacterial drugs.
Alexander Fleming performed the first clinical trials with penicillin, demonstrating its effectiveness as a chemotherapeutic agent.
Semisynthetic penicillins are more effective antibiotics than is natural penicillin.
Some drug combinations are synergistic; therefore, when taken together, they are more effective.
The method of action of nucleoside analogs is
inhibition of nucleic acid synthesis
Which drug would be used to treat athlete's foot?
Which of the following antibiotics inhibits folic acid synthesis?
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