-Howell-Jolly Bodies (Dark DNA nuclear remnants) * Also present with asplenic patients.Sickle Cell Disease - Peripheral blood smear
-Sickle cells with anisocytosis"Auto infarcted" splenic remnant in Sickle Cell DiseaseSpleen in sick cell disease
Low power - Red pulp cords and sinusoids are markedly congested; between congested areas, pale areas of fibrosis resulting from ischemic damage are evident
High power - splenic sinusoids are dialted and filled with sickled red cell.sSickle cell diseaseHemoglobin C
-HbC crystalsHemosiderin containing macrophages in alveoli of lungs are pulmonary hemorrhage.
Example of hemosiderin (iron-storage complex found within cells as opposed to blood).Glucose-6-phosphate dehydrogenase deficiency (G6PD)Anemia with Following Flow CytometryGlucose-6-phosphate dehydrogenase deficiency (G6PD)
Heinz bodies which are denatured hemoglobin revealed by supravital staining. Splenic macrophages pluck out the inclusion leaving bite cells.RBCs Agglutination --> Immuno hemolytic anemia (IHA)Microangiopathic Hemolytic Anemia - Blood Smear
Microthrombi*, Prosthetic heart valves, or aortic stenosis (AS) --> Mechanical damage/destruction of RBCs --> intravascular hemolytic.
Microthrombi usually seen in TTP, HUS, DIC, and HELLP (Hemolysis, Elevated Liver enzymes and decrease platelets.)Aplastic Anemia - Bone Marrow Biopsy
Hypocellular marrow contains mainly fat.