Pathology II: RBC Pictures

Iron deficiency anemia

-Microcytic
-Hypo chromatic
-Increased red cell distribution width (RDW)
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Terms in this set (22)
Iron deficiency anemia

-Microcytic
-Hypo chromatic
-Increased red cell distribution width (RDW)
Image: Iron deficiency anemia -Microcytic -Hypo chromatic -Increased red cell distribution width (RDW)
Iron deficiency anemia

-Microcytic
-Hypo chromatic
-Increased red cell distribution width (RDW)
Image: Iron deficiency anemia -Microcytic -Hypo chromatic -Increased red cell distribution width (RDW)
Anemia of Chronic Disease

Bone marrow biopsy with iron stain
Image: Anemia of Chronic Disease Bone marrow biopsy with iron stain
Sideroblastic Anemia - Peripheral Smear
-Iron stain highlights the ring of mitochondria loaded with iron around the nucleus of the erythroblasts
Image: Sideroblastic Anemia - Peripheral Smear -Iron stain highlights the ring of mitochondria loaded with iron around the nucleus of the erythroblasts
Sideroblastic Anemia - Bone Marrow Smear
-Iron stain highlights the ring of mitochondria loaded with iron around the nucleus of the erythroblasts
Image: Sideroblastic Anemia - Bone Marrow Smear -Iron stain highlights the ring of mitochondria loaded with iron around the nucleus of the erythroblasts
Beta Thalassemia
Note target cells
Image: Beta Thalassemia Note target cells
Beta Thalassemia
Note target cells
Image: Beta Thalassemia Note target cells
X-ray film of the skull showing new bone formation on the outer table, producing perpendicular radiations resembling crewcut.

Thalassemia OR Sickle Cell Disease
Image: X-ray film of the skull showing new bone formation on the outer table, producing perpendicular radiations resembling crewcut. Thalassemia OR Sickle Cell Disease
Megaloblastic Anemia
(B9(Folate) or B12 Deficiency - Types of Macrocytic Anemias)

Note the hyper segmented neutrophil with six-lobed nucleus and enlarged RBCs (RBCs should be significantly smaller).
Image: Megaloblastic Anemia (B9(Folate) or B12 Deficiency - Types of Macrocytic Anemias) Note the hyper segmented neutrophil with six-lobed nucleus and enlarged RBCs (RBCs should be significantly smaller).
Reticulocytes

Network of ribosomal RNA become visible with microscope with methylene blue and Romanowsky stain.
Image: Reticulocytes Network of ribosomal RNA become visible with microscope with methylene blue and Romanowsky stain.
Hereditary Spherocytosis -Spherocytes -Howell-Jolly Bodies (Dark DNA nuclear remnants) * Also present with asplenic patients.Sickle Cell Disease - Peripheral blood smear -Sickle cells with anisocytosis"Auto infarcted" splenic remnant in Sickle Cell DiseaseSpleen in sick cell disease Low power - Red pulp cords and sinusoids are markedly congested; between congested areas, pale areas of fibrosis resulting from ischemic damage are evident High power - splenic sinusoids are dialted and filled with sickled red cell.sSickle cell diseaseHemoglobin C -HbC crystalsHemosiderin containing macrophages in alveoli of lungs are pulmonary hemorrhage. Example of hemosiderin (iron-storage complex found within cells as opposed to blood).Glucose-6-phosphate dehydrogenase deficiency (G6PD)Anemia with Following Flow CytometryGlucose-6-phosphate dehydrogenase deficiency (G6PD) Heinz bodies which are denatured hemoglobin revealed by supravital staining. Splenic macrophages pluck out the inclusion leaving bite cells.RBCs Agglutination --> Immuno hemolytic anemia (IHA)Microangiopathic Hemolytic Anemia - Blood Smear -Schistocytes -Helmet cells Microthrombi*, Prosthetic heart valves, or aortic stenosis (AS) --> Mechanical damage/destruction of RBCs --> intravascular hemolytic. Microthrombi usually seen in TTP, HUS, DIC, and HELLP (Hemolysis, Elevated Liver enzymes and decrease platelets.)Aplastic Anemia - Bone Marrow Biopsy Hypocellular marrow contains mainly fat.