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table 9-1 anticholinesterases (edrophonium vs. neostigmine vs pyridostigmine)

Terms in this set (9)

which has the shortest elimination 1/2 time? longest?
neostigmine 77 min
pyridostigmine 112
which meds e 1/2 will be impacted the most in the anephric patient?
pyridostigmine 112 --> 379
which have Vd > 1 L/kg? which have <1?
edrophonium = pyridostigmine 1.1
neostig 0.7
rank most to least renal contribution to clearance
pyrido 76% > edrophon 66% > neostig 54%
rank the speed of onset from fastest to slowest
edro > neo> pyrid
rank the DOA from longest to shortest
pyrido > neostig >edrophon
which has presynaptic site of action? which has postsynaptic site of action?
edro - pre
neo and pyrid - post
what dose of atropine is required for these meds?
edrop - 7mcg/kg (10-15 if an opioid-based anesthetic)
neo and pyrido - 20 mcg/kg
what dose of glyco is required for these meds?
edro - none required
neo and pyrido - 10 mcg/kg/min
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