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Signal Transduction (cAMP)

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step 1: Ligand binds (Reception)

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Terms in this set (13)

step 1: Ligand binds (Reception)

ligand binds to the G-protein Coupled Receptor (GPCR).

Image: step 1: Ligand binds (Reception)

step 2: GPCR is activated
(Reception)

binding of the ligand (hormone) activates the GPCR.

Image: step 2: GPCR is activated
(Reception)

step 3: GPCR binds to G protein
(Transduction)

active GPCR is able to bind the G-protein

Image: step 3: GPCR binds to G protein
(Transduction)

step 4: G protein activated (Transduction)

G-protein ejects a GDP accepts a GTP

G-protein=active

Image: step 4: G protein activated (Transduction)

step 5: G protein splits

(Transduction)

G-protein α subunit with GTP disassociates from the β and γ subunits

Image: step 5: G protein splits

(Transduction)