Chapter 5 Complement

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The complement system is: (a) a heat-labile series of plasma proteins. (b) composed of many proteinases. (c) composed of 3 interrelated pathways. (d) all the above.

(d) all the above.

All the following are complement-controlling protens EXCEPT: (a) C1 [INH]. (b) Factor I. (c) Factor H. (d) C3.

(d) C3.

Various cell types express surface membrane glycoproteins that react with one or more of the fragments of ___ produced during complement activation and degradation. [C1, C3, C5, or C8]


All the following result from complement activation EXCEPT: (a) decreased cell susceptibility to phagocytosis. (b) blood vessel dilation and increased vascular permeability. (c) production of inflammatory mediators. (d) Cytolysis or hemolysis.

(a) decreased cell susceptibility to phagocytosis.

Complete the following activation sequence of the classic complement pathway: C1-C_(5)-C_ _(6)-_ _-C3-_C(7)_-C6-C7-C_(8)_ _-C9

(5) 4
(6) 2
(7) 5
(8) 8

Which complement component is present in the treatest quantity in plasma? [2, 3, 4, or 8]


Arrange the three stages of the classic complement pathway in their correct sequence. [Enzymatic activation, Membrane attack, and Recognition]

2.Enzymatic activation
3.Membrane attack

Fixation of the C1 complement component is related to each of the following factors EXCEPT: (a) Molecular weight of the antibody. (b) the presence of IgM antibody. (c) the presence of most IgG subclasses. (d) Spatial constraints.

(a) Molecular weight of the antibody.

At which stage does the complement system reach its full amplitude? (a) C1q, C1r, C1s complex. (b) C2. (c) C3. (d) C4.


Which of the following is NOT a complement of the membrane attack complex? [C3b, C6, C7, or C8]


The final steps (C8 and C9) in complement activation lead to: (a) Cell lysis. (b) Phagocytosis. (c) Immune opsonin adherence. (d) Virus neutralization.

(a) Cell lysis.

Select the appropriate pathway response: [Classic pathway, Alternate pathway, or Both]
1. __Activated by antigen-antibody compleses.
2. __Generates a C3 convertase.
3. __Activated by microbial and mammalian cell surfaces.
4. __Terminates in a membrane attack complex.

1. Classic
2. Classic
3. Alternate
4. Classic and Alternate

The alternate complement pathway is/can be: (a) Initiated by the formation of antigen-antibody rxns. (b) Predominantly a non-antibody-initiated pathway. (c) Activated by factors such as endotoxins. (d) Both b and c.

(d) Both b and c.

Which of the following conditions can be associated with hypercomplementemia? (a) Myocardial infarction (b) Systemic lupus erythematosus (c) Glomerulonephritis (d) Subacute bacterial endocarditis

(a) Myocardial infarction

Match the following complement deficiency states in humans with their respctive deficient components. (Use an answer only once.)
1. __C2 a. Neisseria infections
2. __C5 b. Leiner's disease
3. __C6 c. Raynaud's phenomenon
4. __C7 d. Recurrent pyogenic infections

C2 - Recurrent pyogenic infections
C5 - Leiner's disease
C6 -Neisseria infections
C7 - Raynaud's phenomenon

A (The) nonspecific component(s) of the immune system is (are)
a. Complement
b. T cells
c. Both a. and b.


Match the following.
1. __Interleukin-1 (IL-1)
2. __Interleukin-2 (IL-2)
3. __Interleukin-3 (IL-3)
4. __Interleukin-5 (IL-5)

a. T-cell growth factor
b. Lymphocyte-activating factor
c. B cell growth factor 2
d. Multicolony colony-stimulating factor

IL-1.....Lymphocyte-activating factor
IL-2.....T-cell growth factor
IL-3.....Multicolony colony-stimulating factor
IL-5.....B cell growth factor 2

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