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Pharm KMK Antihistamines

Terms in this set (15)

What is the MOA of antihistamines?
Block type 1 hypersensitivity reactions by blocking the receptors that histamine acts on
Type 1 hypersensitivity is mediated by which antibody?
A. IgM
B. IgA
C. IgE
D. IgG
C
List the mast cell stabilizers
Carolyn wears Aloe Masks
-Cromolyn Sodium
-Alocril
-Alomide
-Alomast
What is the MOA of mast cell stabilizers?
Stabilize voltage gated Ca++ Channels to prevent Ca2++ from depolarizing the mast cell, the degranulation of the mast cell preventing the release of histamine
List the antihistamine / mast cell stabilizer combination drugs
Combo KATs dont like Em
-Ketotifen
-"astine"
-"tadine"

(NOT Emedastine)
Which of the following is an H1 receptor blocker only?
A. Bepotastine
B. Epinastine
C. Elastat
D. Emedastine
E. Pataday
D
Explain the type 1 hypersensitivity reaction step by step.
Step 1: 1st exposure: IgE antibody binds to mast cell
Step 2: 2nd exposure: Antigen binds to IgE antibody at the Fab region, IgE cross links with the antibody next to it which opens voltage gated Ca++ channels
Step 3: Ca2++ ions depolarize the cell causing degranulation of the mast cell releasing Histamine into the bloodstream.
Step 4: Histamine binds to H1 receptors of cells causing allergic symptoms
Where on the IgE antibody does the antigen bind to?
A. Fab region
B. FC region
C. H1 receptor
A
The Fab region of the IgE antibody contains ____ and _____.
Heavy and Light chains
Histamine is found in which two types of cells?
A. Macrophages
B. Mast Cells
C. Eosinophils
D. Basophils
E Neutrophils
B, D
Which of the following antihistamine drugs causes immediate relief?
A. Alamast
B. Olopatadine
C. Ketotifen
D. Pataday
E. Emadastine
E
All of the following can be used in seasonal or perennial allergies for long term relief preventing future symptoms except:
A. Cromolyn Sodium
B. Alocril
C. Azelastine
D. Emedastine
E. Bepotastine
D
Which of the following is best for ocular itching and allergic conjunctivitis as well as relief of acute symptoms?
A. Nedocromil
B. Lodoxamide
C. Emadine
D. Olopatadine
E. Pemirolast
D
Which of the following would you prescribe for chronic allergic vernal conjunctivitis?
A. Cromolyn sodium
B. Emadine
C. Bepotastine
D. Olopatadine
E. Epinastine
A
Which of the following would you prescribe for atopic keratoconjunctivitis?
A. Lodoxamide
B. Azelastine
C. Emedastine
D. Ketotifen
E. Elestat
A
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