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Pharm KMK Steroids

Terms in this set (13)

What happens during flight or flight response in the body?
Ant Pit. releases ACTH which acts on the adrenal glands (located above the kidneys) which releases steroids (cortisol)
What are the 3 major ocular side effects of steroids?
1. PSC cats
2. 2ndary infection (herp simplex)
3. Glaucoma
If a patient has PSC cataracts, when would they notice it ?
When focusing at near bc the pupil constricts and PSC cats are located centrally
Why do steroids cause secondary infections?
Bc it decreases the immune response
How do steroids cause glaucoma?
It causes an outflow issue at the corneoscleral meshworkd
What is the MOA of steroids?
Steroids inhibit PHOSPHOLIPASE A2 which inhibits the arachidonic acid pathway resulting in a decrease in inflammation and decrease in immune response.

-Decrease in inflammatory mediators which leads to a decrease in capillary permeability and a decrease in immune system response

- Steroids decrease fibroblast and collagen formation which decrease wound healing
List steroids from potent to soft.
1. Difluprednate
2. Prednisolone acetate
3. Dexamethasone
4. Rimexolone

5. Fluorometholone
6. Loteprednol
Which of the following is the most potent ?
A. Prednisolone Acetate
B. Fluorometholone
C. Difluprednate
D. Rimexolone
E. Loteprednol
C
Which of the following is the safest?
A. Prednisolone Acetate
B. Fluorometholone
C. Difluprednate
D. Rimexolone
E. Loteprednol
E
Which of the following acts on Phospholipase A2?
A. Rimexolone
B. Diclofenac sodium
C. Plaquenil
D. Montelukast
E. Hydroxychloroquine
A, C, E
What systemic SE do both NSAIDS and steroids have?
peptic ulcer
Which of the following contains an ester base and therefore has the least side effects?
A. Loteprednol
B. Fluorometholone
C. Rimexolone
D. Dexamethasone
E. Difluprednate
A
All of the following contain ketones except:
A. Loteprednol
B. Fluorometholone
C. Rimexolone
D. Dexamethasone
E. Difluprednate
A
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