Create an account
The B cell becomes a plasma cell when __.
The antigen binds to the Igs and allows B cell to proliferate.
This plasma cell will now secrete __ which have the same __ as __.
Antibodies; specificity; BCR (membrane bound Igs).
Antibodies produced by a __ response have a higher __ than those in __ response.
Secondary memory response; affinity; primary response.
Valence of an antibody is __.
The maximum number of antigenic determinants with which the antibody can react.
Avidity is the __.
Firmness of association between multideterminant antigen and the antibodies produced against it.
The protease __ cleaves the antibody into three pieces __.
Papain; IgG into three pieces Fab (2) and Fc (1).
In the five main isotypes IgGAMED the differences are defined by the __.
Heavy chain constant regions where the differences lie in the length and sugars of the heavy chain.
Each class contains different __ chains and corresponding differences in their __.
It is the only antibody known to cross the __ and provide __ to a newborn.
Placenta; passive humoral (innate) immunity to a developing and newborn infant.
SC is part of the molecule __.
Poly-Ig receptor involved in transepithelial transport of exocrine IgA and stabilizes IgA against proteolytic degradation.
IgA is secreted __ and is synthesized locally by __.
Dimerically; plasma cells in mammary and salivary glands.
IgM and IgD interact with a pathogen this leads to being __ and then __.
Presented to helper T cells; proliferation and differentiation into plasma cells.
Plays significant roles in __ (2).
Enhancing acute inflammation; protection from infection by worms.
Sometimes the isotypes may differ in the length of __.
Heavy chain C-Regions and locations of the disulfide bonds.
Hinge region is a __ region allowing for __.
Flexible; independent movement of the Fab arms (0, 60, 90).
The V domains of heavy and light chains have __ regions flanked by __ regions.
Hypervariable (HV); Framework .
The bringing together of these hypervariable loops creates a __ surface that forms the __.
Composite hypervariable; antigen-binding site.
You can have antigens with multivalent __ and __ type epitopes.
Repeated different or repeated same .
Discontinuous epitopes are __.
Where the amino acid sequence is not linear, but folding causes them to be together.
Kohler and Milstein produced a procedure to create __.
Cell lines producing monoclonal antibodies mAb.
Ig H-chain and L-chain loci consists of families of gene segments containing __.
Alternative versions of parts of the Ig variable region.
Germ-line DNA contains __.
Multiple gene segments that code for portions of a single Ig heavy or light chain.
During development a single B cell randomly selects from its H-Chain gene group __.
One V, D, and J.
The B cell will then select for its light chain from the __ or __ group selecting __.
Kappa; lambda; V and J.
In the peripheral lymphoid organs the Mature B cell becomes an __ and differentiates into __.
Activated B cell; plasma cell.
Different segments encode __, __, and __.
Leader peptide (L), variable region (V), and constant regions (C).
The first and second hypervariable regions (CDR) of light-chain are encoded by different __ and the third CDR is determined by the __.
V segments; V/J junction.
Each RSS contains a conserved __ and __ sequence.
Palinodromic heptamer; conserved AT-rich nonamer sequence.
When RAG binds one to each spacer and it cleaves the DNA the circular DNA produced is called __.
Signal joint and serves no purpose.
When __ this is called allelic exclusion.
Rearranged heavy chain or light chain is expressed from only one chromosome.
Allelic exclusion shuts down __.
Recombination machine and stopping shuts RAG 1 and RAG 2 down which is why BCR are exactly the same.
Upon encountering a specific antigen, many B cells change the isotype that to produce to __ (3).
IgG, IgA, and Ig E.
IgAlpha and IgBeta have longer __.
Cytoplasmic tails than Ig and interact with intracellular signaling molecules.
Gene rearrangement of immature B cell leads to the expression of __.
Functional heavy and light chains.
Mechanism involves __.
AID - Activation-induced cytidine deaminase an enzyme that converts cytidine to uracil for excision and replacement with non-templated nucleotides.
Please allow access to your computer’s microphone to use Voice Recording.
Having trouble? Click here for help.
We can’t access your microphone!
Click the icon above to update your browser permissions and try again
Reload the page to try again!Reload
Press Cmd-0 to reset your zoom
Press Ctrl-0 to reset your zoom
It looks like your browser might be zoomed in or out. Your browser needs to be zoomed to a normal size to record audio.
Please upgrade Flash or install Chrome
to use Voice Recording.
For more help, see our troubleshooting page.
Your microphone is muted
For help fixing this issue, see this FAQ.
Star this term
You can study starred terms together