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Nucleus has two lobes; contains granules of lysosomal enzymes; functions in attacking parasitic worms.
Contains a U- or an S-shaped nucleus; granules stain very dark; releases histamine and heparin
Largest of the WBCs; crucial in defense against viruses; associated with chronic infections
Transport proteins that bind to lipids, metal ions, and fat-soluble vitamins.
Alpha and Beta Gobulins
The primary source of RBCs in the adult human being is the bone marrow in the shafts of the long bones.
False - Found in the bones of Axial Skeleton and Girdles - and in the proximal epipsys of humerus and femur
The process of fibrinolysis disposes of bacteria when healing has occurred.
False - removes clots when healing has occurred. Without blood vessels would becomes blocked
White blood cells are produced through the action of colony-stimulating factors.
True - 2 families 1) Interlukeins 2) Colony stimulating factors
Hemoglobin is made up of the protein heme and the red pigment globin.
False - Protein globin and red heme pigment
Each HEME contains an atom of iron and can transport one molecule of oxygen.
True - each iron can combine reversibly w/one molecule of oxygen
Diapedesis is the process by which red blood cells move into tissue spaces from the interior of blood capillaries.
False - WBC's are able to do this NOT WBC
A condition of leukocytosis indicates over 11,000 white blood cells per cubic millimeter in the blood.
A person with type B blood could receive blood from a person with either type B or type O blood.
Leukocytes move through the circulatory system by amoeboid motion.
False- they move through tissue spaces at the site of infection
Granulocytes called neutrophils are phagocytic and are the most numerous of all white blood cell types.
Myelocytic leukemia involves a cancerous condition of lymphocytes.
False - involves myeloblast descendants
Which of the following is a pivotal molecule associated with the external surfaces of aggregated platelets and is involved in the intrinsic and extrinsic mechanisms of blood clotting?
Which of the choices below is the parent cell for all formed elements of blood?
Pluripotent stem cell (hemocytoblast)
Which of the statements below is an incorrect or false statement?
Blood typing for the Kell, Lewis, and Duffy factors is always done before a blood transfusion.
An individual who is blood type AB negative can ________.
receive any blood type in moderate amounts except that with the Rh antigen
When neither anti-A sera nor anti-B sera clot on a blood plate with donor blood, the blood is type ________.
Select the correct statement regarding blood cell formation.
Red marrow is the main site of blood cell formation throughout adult life.
Place the following in correct developmental sequence:
2, 4, 3, 1
proerythroblast, late erythroblast, normoblast, reticulocyte
A lack of intrinsic factor, leading to a deficiency of vitamin B12 and large pale cells called macrocytes, is characteristic of ________.
Thromboembolic disorders ________.
include embolus formation, a clot moving within the circulatory system
Which of the following is not a cause of bleeding disorders?
excess secretion of platelet-derived growth factor (PDGF)
Which sequence is correct for the following events?
formation of thromboplastin, prothrombin → thrombin, fibrinogen → fibrin, clot reaction
Fred's blood was determined to be AB positive. What does this mean?
There are no antibodies to A, to B, or to Rh antigens in the plasma.
Sickling of red blood cells can be produced in those with sickle-cell anemia by ________.
travel at high altitude and vigorous exercise
When can erythroblastosis fetalis not possibly happen in the child of an Rh negative mother?
when the father is Rh-
Complications of aplastic anemia generally do not include ________.
increase of leukocytes as a result of erythrocyte loss
Potent platelet aggregates that attract more platelets to the site of an injury are ________ and ________.
ADP and Thromboxane Serotonin
Destruction of the hematopoietic components of red marrow leads to a condition called ________.
________ is the stage of development in the life of an erythrocyte during which the nucleus is ejected.
List the general factors that limit normal clot growth
removal of clotting factors
Aspirin - an antiprostaglandin that inhibits thromboxane A2
Heparin - an anticoagulant used clinically for pre- and postoperative cardiac care
Warfarin (trade name Coumadin) - used for those prone to atrial fibrillation
List the most common causes of bleeding disorders
Thrombocytopenia - condition of decreased circulating platelets with vitamin K deficiency and defective clotting cascade
List one example for each of these three functions of blood: distribution, regulation, and protection
Distribution - delivering O2 from lungs and waste
Regulation - maintenance of normal ph in body tissues
Protection - prevention of blood loss
List the granulocytes and describe their granules
Neutrophil - fine, faint pink granules
Eosinophil - full of pink-orange granules
Basophil - large dark deep purple ganules
Why is iron not stored or transported in its free form? In what form(s) is it stored or transported in blood?
Because iron can be toxic. Intracellular iron is stored in protein-iron complexes such as ferritin and hemosiderin.
The body stores iron in Hb (65%), the liver, spleen, and bone marrow
Circulating iron is loosely bound to the transport protein transferrin
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