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MSK - Rheumatology Disorders

Terms in this set (180)

rheumatism
any disease marked by inflammation and pain in the joints, muscles, or fibrous tissue, especially rheumatoid arthritis
What is the pathogenesis of autoimmune diseases?
-genetic susceptibility
-triggering event such as viral infection, chemical exposure, or hormone status change
What are the 2 categories of systemic rheumatic diseases?
-systemic autoimmune rheumatic diseases (SARDs)
-systemic rheumatic disease
Which diseases have a pathogenesis that includes the presence of serum autoantibodies that are B-cell generated antibodies directed against self-antigens/tissues?
systemic autoimmune rheumatic diseases (SARDs)
What are the systemic autoimmune rheumatic diseases (SARDs)?
-Rheumatoid arthritis
-System Lupus Erythematosus
-Sjögrens Syndrome
-Systemic Sclerosis
-Polymyositis and Dermatomyositis
What are autoantibodies directed against components of the cell nucleus and is generally (+) in individuals with SARDs?
antinuclear antibodies (ANA)
True or False:
Some healthy individuals will have a (+) ANA but NO disease.
True

-therefore the ANA tends NOT to be the diagnostic test
May individuals have autoantibodies...
...but NO disease.
When does a (+) ANA strongly support the presence of a SARD?
with signs and symptoms of a SARD
The more positive the ANA...
...the more worried we are that is autoimmune.
What does a (-) ANA indicate?
excludes SLE
What does a (+) ANA indicate?
-order rest of panel
-refer to rheumatologist
What is the primary test for rheumatoid arthritis?
rheumatoid factor
What are autoantibodies directed against various cell membranes, particularly mitochondrial membranes, is most famously associated with SLE and recurrent thrombosis?
anticardiolipin antibodies (aka antiphospholipid)
Which diseases have a pathogenesis that includes abnormal immune functioning but do NOT have autoantibodies and instead have cellular immune components present, such as T-cell macrophages?
systemic rheumatic diseases
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