46 terms

Path Ch 4 HIV

How is HIV spread
Infected blood/blood products
Mother to baby
Which cells are mainly affected in HIV
CD 4 T-helper cells
Which immunity does T-helper cells participate in
Cell mediated immunity & regulating immune response
How do you diagnose AIDS
HIV with CD4 depletion
CD4 less than 200
What is a normal CD 4 level
Testing for HIV first test
ELISA-Test for circulating antibiodies
2nd test for HIV
2 positive ELISA do
Western blot test
Circulating antibodies
What does the AIDS virus infect
Cells of the immune system
Symptoms of AIDS related complex
Weight loss
When does the antibodies to HIV become detectable
6 weeks after infection
Definiton of window of infectivity
Antibodies may not be detectable for 6 months-1 yr or longer
What test measures the amount of HIV circulating in serum
Only test that doesn't measure circulating antibody
2 ways to assess HIV infection
Measure viral load
CD4 cell count
Pt management of HIV include
Antiretroviral meds
Drugs to treat opportunistic infections
Oral lesions occur due to what
Deficiency in CMI (cell mediated immunity) & depletion of T helper cells
Oral manifestations of AIDS
Hairy Leukoplakia
Kaposi Sarcoma
Bilateral salivary gland enlargement
Treatment of Candidiasis in HIV pt
Topical/Systemic antifungal meds
Recurrence is common
What does candidiasis signal
Beginning of progresively severe immunodeficiency
Herpes not resolved in 1 month means
Diagnosis of AIDS
Herpes Zoster signals
Developing immunodeficiency
What is hairy leukoplakia
Epstein barr virus
Where does hairy leukoplakia occur
Lateral borders of tongue
What can hairy leukoplakia also resemble
Chronic tongue chewing & hyperplastic candidiasis
What is the most reliable method of diagnosis of hairy leukoplakia
Epstein barr virus being present
Hairy leukoplakia is a predictor of what
Progression of HIV to AIDS
What must you rule out with hairy leukoplakia
HIV infection
HPV in HIV pt may be associated with what
Antiretroviral tx
What is Kaposi sarcoma
Opportunistic neoplasm
Where is Kaposi sarcoma usually located
How do you diagnose Kaposi sarcoma
Tx of Kaposi sarcoma
Surgical removal
Radiation tx
What is lymphoma
Malignant tumor
How do we treat lymphoma
What perio dz may a HIV pt have
Linear gingival erythema (red band around teeth)
NUP-Necrotizing ulcerative perio
Characteristics of linear gingival erythema
Punctate/petechiae on attached gingiva or alveolar mucosa
Band like redness on gingiva that is non responsive to tx
T/F linear gingival erythema occurs independant of OH status
Charcteristics of NUP
Intense redness
Extreme rapid bone loss
What is necrotizing stomatitis
Extensive focal areas of bone loss along with NUP
Tx of perio dz in HIV pt
Soft tissue curettage
Intrasulcular lavage
Flagyl (systemic metronidazole)
What causes spontaneous gingival bleeding in HIV pt
Decrease in platelets
What causes a decrease in platelets in HIV pt
Autoimmune type of thrombocytopenic purpura
What needs to be considered before deep scaling of HIV pt with lower platelets
Platelet count and bleeding time
Charcteristics of aphthous ulcers in HIV pt
Increase in # of ulcers
Resemble major apththous ulcers
Lesions respond to steroids
What may salivary gland enlargement in HIV pt be related to
Meds or salivary gland disease
What is mucosal melanin pigmentation
Macular areas of melanin pigmentation
Cause unclear
Definitive Diagnosis of AIDS
Hairy Leukoplakia
Kaposi sarcoma
Herpes simplex lesion lasting > 1 month
Herpes zoster
Aphthous ulcers
Salivary gland enlargement
Mucosal pigmentation
Oral lymphoma
< 200 CD4 T cell count
Esophageal candidiasis
Invasice cervical cancer