Upgrade to remove ads
Only $35.99/year

Lipid Metabolism

Terms in this set (45)

Where does fatty acid synthesis occur?
Cytoplasm
Fatty acid synthesis requires what?
NADPH
Where does fatty acid synthesis get the NADPH it needs?
Pentose phosphate pathway
Malic Enzyme
What adds carbons to a growing fatty acid chain?
Malonyl-CoA
How is malonyl-CoA formed?
From acetyl-CoA + bicarbonate (via acetyl-coA carboxylase)
What activates the formation of malonyl-CoA?
Insulin (increased glucose levels)
Carbons are added to fatty acid chains by ___
Twos (add 3, remove 1 from CO2)
What acts as a shuttle to move substrates within the fatty acid synthase protein?
Acyl carrier protein (ACP)
How does oxaloacetate cross the mitochondrial cell membrane?
It is converted to malate
Most malate in the cytosol is used to generate what?
NADPH
What is the fate of malate?
Most of the malate in the cytosol is used to make NADPH by converting it to pyruvate
What is the rate limiting step in fatty acid synthesis?
Carboxylation of acetyl-CoA to malonyl-CoA via acetyl-CoA carboxylase
Fatty acid synthesis is activated by:
Insulin and citrate
Fatty acid synthesis is inhibited by:
Glucagon and epinephrine
Where does the synthesis of long fatty acid chains occur?
Smooth ER + mitochondria
Other sets by this creator