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Pharmacology Quiz 1

Terms in this set (19)

What is dissolution?
the process in which one substance is dissolved in another
What is the first pass effect?
drugs absorbed from the GI tract enter the portal vein and pass through the liver before entering circulation.

accounts for the larger difference between oral and IV dosages.
What is the role of protein, specifically albumin, in pharmacokinetics? How does this affect drug therapy?
Albumin possesses specific sites for acidic and basic drug binding This may affect the binding of drugs in target molecules inducing significant pharmacokinetic alterations.
What role does the liver play in pharmacokinetics? How does liver impairment affect drug therapy?
change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug. A cause of a drug interaction involves one drug which alters the pharmacokinetics of another medical drug
What role do the kidneys play in pharmacokinetics? How does kidney impairment affect drug therapy?
· Excretes the medication, without it you will have an increased likelihood of toxicity.
What is half-life, and how does half-life affect drug dosing schedules?
the concentration of the drug in the body will be half of the starting dose. With each additional half-life, proportionately less of the drug is eliminated. However, the time required for the drug to reach half of the original concentration remains constant
What is the therapeutic index of a drug? Why is this important to the patient?
A ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective. The larger the therapeutic index (TI), the safer the drug is.
What are drug interactions?
change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug. A cause of a drug interaction involves one drug which alters the pharmacokinetics of another medical drug
What should the nurse do if a medication error occurs?
Check on patient, tell them what happened, contact physician, contact pharmacy, then make incident report and then document.
Nine Rights of Medication Administration
1. Right Patient
2. Right Medication
3. Right Dose
4. Right Time
5. Right Route
6. Right Documentation
7. Right Reason
8. Right Response
9. Right to Refuse
Right patient
requires confirmation of a patient's identity with two forms of identification before drug administration
Right Reason
inform patients about why the provider has prescribed the medication for them
Right Medication
check the label three times to verify the medication, strength and dose
Right Dose
Written order must include the patient name, the drug name? The dosage form and route, the dosage to be administered and frequency
Right Route
Know the correct route of administration by which the drug should be given, and that it matches with what is ordered.
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