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Chapter 12

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Goal of antimicrobial therapy:
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Terms in this set (70)
Selectively toxic to the microbe but nontoxic to host cells Microbicidal rather than microbistatic
* Relatively soluble; functions even when highly diluted in body fluids
* Remains potent long enough to act and not broken down or excreted prematurely
* Does not lead to the development of antimicrobial resistance
*Complements or assists the activities of the host's defenses
* Remains active in tissues & body fluids
* Readily delivered to the site of infection
* Reasonably priced
* Does not disrupt the host's health by causing allergies or predisposing the host to other infections
* Limit drug use - less selective pressure
* Proper drug use - viruses are not affected, use full dose to ensure elimination of pathogens
* Narrow range antibiotics - kill only the targeted microbes; less likely complications
* Multiple drug treatments - drugs can work synergistically; much less likely to get drug resistance.
Antibiotics are common metabolic products of aerobic bacteria and fungi
Bacteria: Streptomyces and Bacillus
Molds: Penicillium and Cephalosporium
*Chemists have created new drugs by altering the structure of naturally occurring antibiotics
*Also Searching for metabolic compounds with antimicrobial effects in species other than bacteria and fungi